An FHIT inhibitor
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8Br-HA

Item No. 34728

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-((4-bromo-6-oxo-7,8,9,10-tetrahydro-6H-benzo[c]chromen-3-yl)oxy)-N-hydroxyacetamide
CAS Number
2937864-01-0
Molecular Formula
C15H14BrNO5
Formula Weight
368.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/ml
SMILES
O=C(OC1=C2C=CC(OCC(NO)=O)=C1Br)C3=C2CCCC3
InChi Code
InChI=1S/C15H14BrNO5/c16-13-11(21-7-12(18)17-20)6-5-9-8-3-1-2-4-10(8)15(19)22-14(9)13/h5-6,20H,1-4,7H2,(H,17,18)
InChi Key
JXEJSQNJFCBFCR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    5 mg

    $95

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    10 mg

    $178

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    25 mg

    $392

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    Cayman Chemical
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    Product Description

    8Br-HA is an inhibitor of fragile histidine triad diadenosine triphosphatase (FHIT; IC50 = 0.12 µM).1 It inhibits the growth of HCC827 and H460 lung cancer cells (GI50s = 0.87 and 5.9 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kawaguchi, M., Sekimoto, E., Ohta, Y., et al. Synthesis of fluorescent probes targeting tumor-suppressor protein FHIT and Identification of apoptosis-inducing FHIT inhibitors. J. Med. Chem. 64(13), 9567-9576 (2021).