A modified nucleobase
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2-Thiocytidine

Item No. 34732

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-thio-cytidine
CAS Number
13239-97-9
Synonyms
  • α-2-Thioribocytidine
Molecular Formula
C9H13N3O4S
Formula Weight
259.3
Purity
≥95%
Formulation (Request formulation change)
A solid
λmax
249, 277 nm
SMILES
OC[C@@H]1[C@@H](O)[C@@H](O)[C@@](N2C=CC(N)=NC2=S)([H])O1
InChi Code
InChI=1S/C9H13N3O4S/c10-5-1-2-12(9(17)11-5)8-7(15)6(14)4(3-13)16-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,17)/t4-,6-,7-,8-/m1/s1
InChi Key
RHFUOMFWUGWKKO-XVFCMESISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $63

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    10 mg

    $118

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    25 mg

    $274

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    Product Description

    2-Thiocytidine is a modified nucleobase found in bacterial and archaeal tRNA.1,2 2-Thiocytidine is also an intermediate in the synthesis of pyrimidine β-ribonucleosides and β-ribonucleotides.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shigi, N. Biosynthesis and functions of sulfur modifications in tRNA. Front. Genet. 5, 67 (2014).

    2. Čavužić, M., and Liu, Y. Biosynthesis of sulfur-containing tRNA modifications: A comparison of bacterial, archaeal, and eukaryotic pathways. Biomolecules 7(1), 27 (2017).

    3. Xu, J., Tsanakopoulou, M., Magnani, C.J., et al. A prebiotically plausible synthesis of pyrimidine β-ribonucleosides and their phosphate derivatives involving photoanomerization. Nat. Chem. 9(4), 303-309 (2017).