A coumarin with diverse biological activities
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Isomer(s)
35827Isomeranzin
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Meranzin

Item No. 34743

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-[[(2S)-3,3-dimethyl-2-oxiranyl]methyl]-7-methoxy-2H-1-benzopyran-2-one
CAS Number
23971-42-8
Molecular Formula
C15H16O4
Formula Weight
260.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
CC1(C)O[C@H]1CC2=C3OC(C=CC3=CC=C2OC)=O
InChi Code
InChI=1S/C15H16O4/c1-15(2)12(19-15)8-10-11(17-3)6-4-9-5-7-13(16)18-14(9)10/h4-7,12H,8H2,1-3H3/t12-/m0/s1
InChi Key
LSZONYLDFHGRDP-LBPRGKRZSA-N
Origin
Plant/Citrus maxima peel
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $109

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    1 mg

    $207

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    5 mg

    $709

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    10 mg

    $1,089

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    Cayman Chemical
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    Product Description

    Meranzin is a coumarin that has been found in Murraya exotica and has diverse biological activities.1,2 It is cytotoxic to NSCLC-N6 and KB cancer cells (IC50s = 14.6 and 12.3 µg/ml, respectively).2 Meranzin (10 mg/kg) increases the latency to paw withdrawal in the hot plate test and reduces xylene-induced ear edema in mice.1 It decreases paw edema induced by carrageenan in rats when administered at the same dose.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wu, L., Li, P., Wang, X., et al. Evaluation of anti-inflammatory and antinociceptive activities of Murraya exotica. Pharm. Biol. 48(12), 1344-1353 (2010).

    2. Kofinas, C., Chinou, L., Loukis, A., et al. Cytotoxic coumarins from the aerial parts of Tordylium apulum and their effects on a non-small-cell bronchial carcinoma cell line. Planta Med. 64(2), 174-176 (1998).