Parbendazole

Parbendazole is an inhibitor of microtubule assembly (EC₅₀ = 3 µM).¹ It reduces viability of HeLa cells (EC₅₀ = 0.53 µM) and induces genotoxic stress in a reporter assay using HEK293 cells.² Parbendazole reduces, but does not eradicate, worm burden in goats with naturally acquired or experimental nematode infections when administered at a dose of 15 mg/kg.³ It is teratogenic to lamb embryos when administered to pregnant ewes at a dose of 60 mg/kg during the third week of pregnancy.

WARNING This product is not for human or veterinary use.

1. Havercroft, J.C., Quinlan, R.A., and Gull, K. Binding of parbendazole to tubulin and its influence on microtubules in tissue-culture cells as revealed by immunofluorescence microscopy. J. Cell Sci. 49, 195-204 (1981).

2. Lo, Y.-C., Senese, S., France, B., et al. Computational cell cycle profiling of cancer cells for prioritizing FDA-approved drugs with repurposing potential. Sci. Rep. 7(1), (2017).

3. Charles, T.P., Pompeu, J., and Miranda, D.B. Efficacy of three broad-spectrum anthelmintics against gastrointestinal nematode infections of goats. Vet. Parasitol. 34(1-2), 71-75 (1989).