A flavonoid with diverse biological activities
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Sophoraflavanone G

Item No. 34755

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S)-2-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-4H-1-benzopyran-4-one
CAS Number
97938-30-2
Synonyms
  • Kushenol F
  • Norkurarinone
  • Vexibinol
Molecular Formula
C25H28O6
Formula Weight
424.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 20 mg/ml
SMILES
C/C(C)=C\C[C@@H](C(C)=C)CC1=C2C(C(C[C@@H](C3=C(O)C=C(O)C=C3)O2)=O)=C(C=C1O)O
InChi Code
InChI=1S/C25H28O6/c1-13(2)5-6-15(14(3)4)9-18-20(28)11-21(29)24-22(30)12-23(31-25(18)24)17-8-7-16(26)10-19(17)27/h5,7-8,10-11,15,23,26-29H,3,6,9,12H2,1-2,4H3/t15-,23+/m1/s1
InChi Key
XRYVAQQLDYTHCL-CMJOXMDJSA-N
Origin
Plant/Sophora flavescens
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $209

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    10 mg

    $341

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    25 mg

    $653

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    Product Description

    Sophoraflavanone G is a flavonoid that has been found in S. flavescens and has diverse biological activities.1,2,3,4 It is active against 21 strains of methicillin-resistant S. aureus (MRSA; MICs = 3.13-6.25 µg/ml) and inhibits the activities of α-glucosidase and β-amylase (Kis = 5.6 and 30.6 µM, respectively).1,2 Sophoraflavanone G is cytotoxic to HL-60 and HepG2 cancer cells (IC50s = 12.5 and 13.3 µM, respectively) and induces apoptosis in HL-60 cells when used at concentrations of 10 or 25 µM.3 It reduces LPS-induced production of prostaglandin E2 (PGE2; Item No. 14010) in RAW 264.7 cells when used at concentrations ranging from 1 to 50 µM.4 Sophoraflavanone G (250 mg/kg) inhibits carrageenan-induced paw edema in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sato, M., Tsuchiya, H., Takase, I., et al. Antibacterial activity of flavanone isolated from Sophora exigua against methicillin-resistant Staphylococcus aureus and its combination with antibiotics. Phytother. Res. 9(7), 509-512 (1995).

    2. Kim, J.H., Ryu, Y.B., Kang, N.S., et al. Glycosidase inhibitory flavonoids from Sophora flavescens. Biol. Pharm. Bull. 29(2), 302-305 (2006).

    3. Ko, W.G., Kang, T.H., Kim, N.Y., et al. Lavandulylfavonoids: A new class of in vitro apoptogenic agents from Sophora favescens. Toxicol. In Vitro 14(5), 429-433 (2000).

    4. Kim, D.W., Chi, Y.S., Son, K.H., et al. Effects of sophoraflavanone G, a prenylated flavonoid from Sophora flavescens, on cyclooxygenase-2 and in vivo inflammatory response. Arch. Pharm. Res. 25(3), 329-335 (2002).