A deoxyhypusine synthase inhibitor
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GC7 (sulfate)

Item No. 34761

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(7-aminoheptyl)-guanidine, monosulfate
CAS Number
150417-90-6
Synonyms
  • N1-Guanyl-1,7-diaminoheptane
Molecular Formula
C8H20N4 • H2SO4
Formula Weight
270.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
10 mM AcOH: Soluble
SMILES
O=S(O)(O)=O.N=C(NCCCCCCCN)N
InChi Code
InChI=1S/C8H20N4.H2O4S/c9-6-4-2-1-3-5-7-12-8(10)11;1-5(2,3)4/h1-7,9H2,(H4,10,11,12);(H2,1,2,3,4)
InChi Key
MDDOWYFCKAAANU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $70

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    10 mg

    $124

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    25 mg

    $272

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    50 mg

    $409

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    Cayman Chemical
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    Product Description

    GC7 is an inhibitor of deoxyhypusine synthase (Ki = 9.7 nM), an enzyme that participates in the biosynthesis of the amino acid hypusine, which is formed post-translationally on eukaryotic initiation factor 5A (eIF5A).1 It inhibits the production of hypusine in CHO cells when used at a concentration of 1 µM. GC7 (20 µM) inhibits activation of eIF5A2 and enhances the cytotoxicity of doxorubicin in Huh7 and HepG2 cells.2 It reduces tumor growth in a Melan-a Tm5 murine melanoma model when administered at a dose of 0.9 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jakus, J., Wolff, E.C., Park, M.H., et al. Features of the spermidine-binding site of deoxyhypusine synthase as derived from inhibition studies. Effective inhibition by bis- and mono-guanylated diamines and polyamines. The Journal of Biological Chemisty 268(18), 13151-13159 (1993).

    2. Lou, B., Fan, J., Wang, K., et al. N1-guanyl-1,7-diaminoheptane (GC7) enhances the therapeutic efficacy of doxorubicin by inhibiting activation of eukaryotic translation initiation factor 5A2 (eIF5A2) and preventing the epithelial-mesenchymal transition in hepatocellular carcinoma cells. Exp. Cell Res. 319(17), 2708-2717 (2013).

    3. Jasiulionis, M.G., Luchessi, A.D., Moreira, A.G., et al. Inhibition of eukaryotic translation initiation factor 5A (eIF5A) hypusination impairs melanoma growth. Cell Biochem. Funct. 25(1), 109-114 (2007).