IM-156 (acetate)

IM-156 is an inhibitor of mitochondrial complex I, also known as NADH dehydrogenase (IC₅₀ = 2.2 µM) and an activator of AMP-activated protein kinase α (AMPKα).^1,2 It reduces the oxygen consumption rate (OCR; IC₅₀ = 3.3 µM) and decreases mitochondrial ATP production in Eµ-Myc mouse lymphoma cells.¹ IM-156 (10, 30, and 50 µM) increases AMPKα activity in primary rat peritoneal mesothelial cells and protects against chlorhexidine-induced peritoneal fibrosis in rats when administered at a dose of 1 mg/kg.² It reduces tumor growth in an AT-84 murine oral cancer model and decreases age-related decline in novel object recognition, spatial working, and contextual memory in mice.^3,4

WARNING This product is not for human or veterinary use.

1. Izreig, S., Gariepy, A., Kaymak, I., et al. Repression of LKB1 by miR-17~92 sensitizes MYC-dependent lymphoma to biguanide treatment. Cell Rep. Med. 1(2), 100014 (2020).

2. Ju, K.D., Kim, H.J., Tsogbadrakh, B., et al. HL156A, a novel AMP-activated protein kinase activator, is protective against peritoneal fibrosis in an in vivo and in vitro model of peritoneal fibrosis. Am. J. Physiol. Renal. Physiol. 310(5), F342-F350 (2016).

3. Lam, T.G., Jeong, Y.S., Kim, S.-A., et al. New metformin derivative HL156A prevents oral cancer progression by inhibiting the insulin-like growth factor/AKT/mammalian target of rapamycin pathways. Cancer Sci. 109(3), 699-709 (2018).

4. Bang, E., Lee, B., Park, J.-O., et al. The improving effect of HL271, a chemical derivative of metformin, a popular drug for type II diabetes mellitus, on aging-induced cognitive decline. Exp. Neurobiol. 27(1), 45-56 (2018).