A peptide hormone
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Hepcidin-25 (trifluoroacetate salt)

Item No. 34768

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-aspartyl-L-threonyl-L-histidyl-L-phenylalanyl-L-prolyl-L-isoleucyl-L-cysteinyl-L-isoleucyl-L-phenylalanyl-L-cysteinyl-L-cysteinylglycyl-L-cysteinyl-L-cysteinyl-L-histidyl-L-arginyl-L-seryl-L-lysyl-L-cysteinylglycyl-L-methionyl-L-cysteinyl-L-cysteinyl-L-lysyl-L-threonine, cyclic (7→23),(10→13),(11→19),(14→22)-tetrakis(disulfide), trifluoroacetate salt
Synonyms
  • H-DTHFPICIFCCGCCHRSKCGMCCKT-OH
Molecular Formula
C113H170N34O31S9 • XCF3COOH
Formula Weight
2789.4
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
O=C(O)C[C@H](N[H])C(N[C@]([C@H](O)C)([H])C(N[C@@H](CC1=CNC=N1)C(N[C@H](C(N2CCC[C@H]2C(N[C@@](C(N[C@@H](CSSC[C@H](N3)C(N[C@@H](CCCCN[H])C(N[C@]([C@H](O)C)([H])C(O)=O)=O)=O)C(N[C@@](C(N[C@H](C(N[C@@H](CSSC[C@H](N4)C(N[C@@H](CSSC[C@H](N5)C3=O)C(N[C@@H](CC6=CNC=N6)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CCCCN[H])C7=O)=O)=O)=O)=O)=O)C(N[C@@H](CSSC[C@H](N7)C(NCC(N[C@@H](CCSC)C5=O)=O)=O)C(NCC4=O)=O)=O)=O)CC8=CC=CC=C8)=O)([H])[C@@H](C)CC)=O)=O)([H])[C@@H](C)CC)=O)=O)CC9=CC=CC=C9)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C113H170N34O31S9.C2HF3O2/c1-8-56(3)86-108(173)132-69(36-60-22-12-10-13-23-60)97(162)139-80-52-183-182-48-76-101(166)140-78-50-185-186-51-79(138-95(160)68(30-35-179-7)126-83(151)43-122-91(156)74(46-180-181-47-75(137-104(80)169)92(157)123-44-84(152)127-76)136-94(159)65(26-16-18-31-114)129-100(165)73(45-148)135-93(158)67(28-20-33-121-113(117)118)128-98(163)70(131-103(78)168)38-62-41-119-54-124-62)105(170)141-77(102(167)130-66(27-17-19-32-115)96(161)146-89(59(6)150)112(177)178)49-184-187-53-81(106(171)143-86)142-109(174)87(57(4)9-2)144-107(172)82-29-21-34-147(82)111(176)72(37-61-24-14-11-15-25-61)134-99(164)71(39-63-42-120-55-125-63)133-110(175)88(58(5)149)145-90(155)64(116)40-85(153)154;3-2(4,5)1(6)7/h10-15,22-25,41-42,54-59,64-82,86-89,148-150H,8-9,16-21,26-40,43-53,114-116H2,1-7H3,(H,119,124)(H,120,125)(H,122,156)(H,123,157)(H,126,151)(H,127,152)(H,128,163)(H,129,165)(H,130,167)(H,131,168)(H,132,173)(H,133,175)(H,134,164)(H,135,158)(H,136,159)(H,137,169)(H,138,160)(H,139,162)(H,140,166)(H,141,170)(H,142,174)(H,143,171)(H,144,172)(H,145,155)(H,146,161)(H,153,154)(H,177,178)(H4,117,118,121);(H,6,7)/t56-,57-,58+,59+,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,86-,87-,88-,89-;/m0./s1
InChi Key
AHYOXSNDCJVSMG-WZCZFSACSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Hepcidin-25 is a peptide hormone that regulates iron homeostasis and has antibacterial activity.1 It is predominantly synthesized by hepatocytes and secreted into the circulation. Hepcidin-25 binds to ferroportin, a membrane-bound iron exporter expressed by macrophages, enterocytes, and hepatocytes, inducing ferroportin internalization and degradation, which increases intracellular iron levels and decreases dietary iron absorption and plasma iron levels. It is bactericidal against multidrug-resistant clinical isolates of Gram-negative and Gram-positive bacteria, including P. aeruginosa, E. coli, K. pneumoniae, S. aureus, S. epidermidis, and E. faecium, when used at concentrations ranging from 6.25 to 50 µg/ml.2 Serum hepcidin-25 levels are increased in patients with chronic kidney disease (CKD).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kroot, J.J.C., Tjalsma, H., Fleming, R.E., et al. Hepcidin in human iron disorders: Diagnostic implications. Clin. Chem. 57(12), 1650-1669 (2011).

    2. Maisetta, G., Petruzzelli, R., Brancatisano, F.L., et al. Antimicrobial activity of human hepcidin 20 and 25 against clinically relevant bacterial strains: Effect of copper and acidic pH. Peptides 31(11), 1995-2002 (2010).

    3. Tsuchiya, K., and Nitta, K. Hepcidin is a potential regulator of iron status in chronic kidney disease. Ther. Apher. Dial. 17(1), 1-8 (2013).