A nitrile glucoside with antitumor activity
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Product Categories

Product Type

Biochemicals
Natural Products
Glycosides

Research Area

Cancer

Lithospermoside

Item No. 34771

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2Z-[(4R,5S,6S)-6-(β-D-glucopyranosyloxy)-4,5-dihydroxy-2-cyclohexen-1-ylidene]-acetonitrile
CAS Number
63492-69-3
Synonyms
  • Griffonin
  • NSC 290807
Molecular Formula
C14H19NO8
Formula Weight
329.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 1 mg/ml
λmax
260 nm
SMILES
N#C/C=C(C=C[C@H]([C@@H]1O)O)\[C@@H]1O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO
InChi Code
InChI=1S/C14H19NO8/c15-4-3-6-1-2-7(17)9(18)13(6)23-14-12(21)11(20)10(19)8(5-16)22-14/h1-3,7-14,16-21H,5H2/b6-3-/t7-,8-,9+,10-,11+,12-,13+,14+/m1/s1
InChi Key
WIIDBJNWXCWLKF-VVAXPEBGSA-N
Origin
Plant/Semiaquilegia adoxoides(DC.)Makino
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    10 mg

    $105

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    25 mg

    $249

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    50 mg

    $471

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    100 mg

    $836

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    Cayman Chemical
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    Product Description

    Lithospermoside is a nitrile glucoside that has been found in Cowania mexicana and has antitumor activity.1 It inhibits activation of Epstein-Barr virus early antigen (EBV-EA) induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014), a marker of tumor formation, in Raji cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ito, H., Miyake, M., Nishatani, E., et al. Anti-tumor promoting activity of polyphenols from Cowania mexicana and Coleogyne ramosissima. Cancer Lett. 143(1), 5-13 (1999).