An alkaloid with diverse biological activities
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Phellodendrine (chloride)

Item No. 34802

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,8,13,13aS-tetrahydro-2,11-dihydroxy-3,10-dimethoxy-7S-methyl-6H-dibenzo[a,g]quinolizinium, monochloride
CAS Number
104112-82-5
Molecular Formula
C20H24NO4 • Cl
Formula Weight
377.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble
SMILES
C[N@+]12[C@](CC3=CC(O)=C(OC)C=C3C2)([H])C4=CC(O)=C(OC)C=C4CC1.[Cl-]
InChi Code
InChI=1S/C20H23NO4.ClH/c1-21-5-4-12-8-19(24-2)18(23)10-15(12)16(21)6-13-7-17(22)20(25-3)9-14(13)11-21;/h7-10,16H,4-6,11H2,1-3H3,(H-,22,23);1H/t16-,21-;/m0./s1
InChi Key
DGLDSNPMIYUWGN-ZOEDVAEJSA-N
Origin
Plant/Phellodendron chinense
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $523

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    Product Description

    Phellodendrine is an alkaloid that has been found in P. amurense and has diverse biological activities.1,2,3 It inhibits acetylcholinesterase (AChE) activity (IC50 = 36.51 µM) and scavenges ABTS (Item No. 27317) radicals in cell-free assays when used at concentrations ranging from 12.5 to 100 µM.2 Phellodendrine induces apoptosis in PANC-1 pancreatic cancer cells and reduces tumor growth in a PANC-1 mouse xenograft model.1 It inhibits the local graft versus host (GVH) reaction in irradiated mice receiving splenocyte grafts, indicating immunosuppressant activity, when administered at a dose of 20 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Thu, P.M., Zheng, Z.-G., Zhou, Y.-P., et al. Phellodendrine chloride suppresses proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis. Eur. J. Pharmacol. 850, 23-34 (2019).

    2. Kim, Y.J., Lim, H.-Y., Kim, Y., et al. Phytochemical quantification and the in vitro acetylcholinesterase inhibitory activity of Phellodendron chinense and its components. Molecules 22(6), 925 (2017).

    3. Mori, H., Fuchigami, M., Inoue, N., et al. Principle of the bark of Phellodendron amurense to suppress the cellular immune response: effect of phellodendrine on cellular and humoral immune responses. Planta Med. 61(1), 45-49 (1995).