A coumarin with diverse biological activities
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Decursinol

Item No. 34807

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(7S)-7,8-dihydro-7-hydroxy-8,8-dimethyl-2H,6H-benzo[1,2-b:5,4-b′]dipyran-2-one
CAS Number
23458-02-8
Synonyms
  • (+)-Decursinol
Molecular Formula
C14H14O4
Formula Weight
246.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 15 mg/mlEthanol: slightly soluble
λmax
331 nm
SMILES
O[C@H]1CC2=CC(C=CC(O3)=O)=C3C=C2OC1(C)C
InChi Code
InChI=1S/C14H14O4/c1-14(2)12(15)6-9-5-8-3-4-13(16)17-10(8)7-11(9)18-14/h3-5,7,12,15H,6H2,1-2H3/t12-/m0/s1
InChi Key
BGXFQDFSVDZUIW-LBPRGKRZSA-N
Origin
Plant/Angelica sinensis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $236

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    25 mg

    $378

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    Cayman Chemical
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    Product Description

    Decursinol is a coumarin that has been found in Angelica gigas and has diverse biological activities.1,2,3,4 It inhibits glutamate-induced neuronal cell death in primary rat mixed cortical cells when used at concentrations of 0.1, 1, and 10 µM. Dietary administration of decursinol (0.004%) reduces decreases in spontaneous alternation induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in the Y-maze, indicating prevention of memory deficits, in mice.2 Decursinol (10 mg/kg) reduces tumor metastasis in a CT26 colorectal cancer mouse xenograft model.3 It inhibits acetic acid-induced writhing in mice when administered at a dose of 50 mg/kg.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kang, S.Y., and Kim, Y.C. Decursinol and decursin protect primary cultured rat cortical cells from glutamate-induced neurotoxicity. J. Pharm. Pharmacol. 59(6), 863-870 (2007).

    2. Yan, J.-J., Kim, D.-H., Moon, Y.-S., et al. Protection against β-amyloid peptide-induced memory impairment with long-term administration of extract of Angelica gigas or decursinol in mice. Prog. Neuropsychopharmacol. Biol. Psychiatry 28(1), 25-30 (2004).

    3. Son, S.H., Park, K.-K., Park, S.K., et al. Decursin and decursinol from Angelica gigas inhibit the lung metastasis of murine colon carcinoma. Phytother. Res. 25(7), 959-964 (2011).

    4. Seo, Y.-J., Kwon, M.-S., Park, S.-H., et al. The analgesic effect of decursinol. Arch. Pharm. Res. 32(6), 937-943 (2009).