A triterpene with diverse biological activities
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Alisol B

Item No. 34808

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(8α,9β,11β,14β,23S,24R)-24,25-epoxy-11,23-dihydroxy-dammar-13(17)-en-3-one
CAS Number
18649-93-9
Synonyms
  • 16-Deoxoalisol C
Molecular Formula
C30H48O4
Formula Weight
472.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 5 mg/mlEthanol: 1 mg/ml
SMILES
C[C@@]12[C@]([C@H](CC3=C([C@H](C)C[C@@H]([C@]4([H])C(C)(O4)C)O)CC[C@@]32C)O)([H])[C@@]5([C@@](C(C)(C(CC5)=O)C)([H])CC1)C
InChi Code
InChI=1S/C30H48O4/c1-17(15-21(32)25-27(4,5)34-25)18-9-13-29(7)19(18)16-20(31)24-28(6)12-11-23(33)26(2,3)22(28)10-14-30(24,29)8/h17,20-22,24-25,31-32H,9-16H2,1-8H3/t17-,20+,21+,22+,24+,25-,28+,29+,30+/m1/s1
InChi Key
GBJKHDVRXAVITG-UNPOXIGHSA-N
Origin
Plant/Alisma plantago-aquatica tubers
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Alisol B is a triterpene that has been found in A. orientale and has diverse biological activities.1,2,3 It increases the number of LC3 puncta, a marker of autophagy, as well as induces cell cycle arrest at the G1 phase and apoptosis, in MCF-7 breast cancer cells when used at a concentration of 30 µM.1 Alisol B (0.5-5 µM) inhibits RANKL-induced osteoclast differentiation of mouse bone marrow-derived macrophages (BMDMs).2 It reduces increases in ear thickness in a mouse model of delayed-type hypersensitivity induced by picryl chloride when administered at doses of 10 or 50 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Law, B.Y.K., Wang, M., Ma, D.-L., et al. Alisol B, a novel inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase pump, induces autophagy, endoplasmic reticulum stress, and apoptosis. Mol. Cancer Ther. 9(3), 718-730 (2010).

    2. Lee, J.-W., Kobayashi, Y., Nakamichi, Y., et al. Alisol-B, a novel phyto-steroid, suppresses the RANKL-induced osteoclast formation and prevents bone loss in mice. Biochem. Pharmacol. 80(3), 352-361 (2010).

    3. Lee, J.H., Kwon, O.S., Jin, H.-G., et al. The rhizomes of Alisma orientale and alisol derivatives inhibit allergic response and experimental atopic dermatitis. Biol. Pharm. Bull. 35(9), 1581-1587 (2012).