An alkylresorcinol
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4-Hexylresorcinol

Item No. 34824

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-hexyl-1,3-benzenediol
CAS Number
136-77-6
Synonyms
  • 4-n-Hexylresorcinol
  • NSC 1570
  • p-Hexylresorcinol
Molecular Formula
C12H18O2
Formula Weight
194.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:4): 0.20 mg/mlPBS (pH 7.2): Slightly soluble
SMILES
OC1=CC(O)=C(CCCCCC)C=C1
InChi Code
InChI=1S/C12H18O2/c1-2-3-4-5-6-10-7-8-11(13)9-12(10)14/h7-9,13-14H,2-6H2,1H3
InChi Key
WFJIVOKAWHGMBH-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 g

    $41

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    25 g

    $71

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    50 g

    $128

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    100 g

    $196

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    Cayman Chemical
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    Product Description

    4-Hexylresorcinol is an alkylresorcinol that has been found in rye.1 4-Hexylresorcinol-containing lozenges are active against S. aureus, S. pyogenes, M. catarrhalis, H. influenzae, and F. necrophorum in an in vitro model of oral transmucosal delivery.2 It increases the activities of glutathione peroxidase (GPX), glutathione reductase (GR), and catalase in isolated human peripheral blood lymphocytes when used at concentrations of 25, 50, or 100 µM.3 4-Hexylresorcinol (2.5 mg/kg) in combination with cisplatin (Item No. 13119) reduces tumor growth and increases survival in a patient-derived xenograft (PDX) mouse model of oral mucosal melanoma.4 Formulations containing 4-hexylresorcinol have been used as food additives to prevent browning in produce and shrimp.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mejbaum-Katzenellenbogen, W., Tłuścik, F., Kozubek, A., et al. Alkylresorcinols in rye (Secale cereale L.) grains. I. Micromethod for determination of alkyl derivatives of resorcinol in rye grain. Acta Soc. Bot. Pol. 44(4), 479-489 (2015).

    2. Matthews, D., Adegoke, O., and Shephard, A. Bactericidal activity of hexylresorcinol lozenges against oropharyngeal organisms associated with acute sore throat. BMC Res. Notes 13(1), 99 (2020).

    3. Yen, G.-C., Duh, P.-D., and Lin, C.-W. Effects of resveratrol and 4-hexylresorcinol on hydrogen peroxide-induced oxidative DNA damage in human lymphocytes. Free Radic. Res. 37(5), 509-514 (2003).

    4. Lee, S.-W., Kim, S.-G., Park, Y.-W., et al. Cisplatin and 4-hexylresorcinol synergise to decrease metastasis and increase survival rate in an oral mucosal melanoma xenograft model: A preliminary study. Tumour Biol. 34(3), 1595-1603 (2013).