An internal standard for the quantification of L-serine
Related Products
Alternative(s)
35126L-Serine-13C3
Unlabeled Version(s)
33561L-Serine
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L-Serine-d7

Item No. 34827

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-serine-N,N,O,1,2,3,3-d7
CAS Number
935275-35-7
Synonyms
  • (S)-Serine-d7
Molecular Formula
C3D7NO3
Formula Weight
112.1
Purity
≥99% deuterated forms (d1-d7)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: soluble
SMILES
[2H]OC([C@](N([2H])[2H])([2H])C([2H])([2H])O[2H])=O
InChi Code
InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1/i1D2,2D,5D/hD3
InChi Key
MTCFGRXMJLQNBG-DTZHYFPHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $54

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    10 mg

    $96

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    25 mg

    $209

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    50 mg

    $315

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    Product Description

    L-Serine-d7 is intended for use as an internal standard for the quantification of L-serine (Item No. 33561) by GC- or LC-MS. L-Serine is a non-essential amino acid.1 It is produced from 3-phosphoglycerate in a multistep biosynthesis catalyzed by phosphoglycerate dehydrogenase (PGDH), phosphoserine aminotransferase (PSAT), and phosphoserine phosphatase (PSP). L-Serine can also be derived from dietary sources, as well as protein and phospholipid turnover. Defective L-serine biosynthesis is associated with neural tube defects and deoxysphingolipid accumulation in patients with Neu-Laxova syndrome, a rare disease characterized by a mutation in PGDH.1,2 Dysregulation of L-serine phosphorylation is associated with disease progression in patients with neurodegenerative diseases, including Alzheimer’s disease and amyotrophic lateral sclerosis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Holm, L.J., and Buschard, K. L-serine: A neglected amino acid with a potential therapeutic role in diabetes. APMIS 127(10), 655-659 (2019).

    2. Metcalf, J.S., Dunlop, R.A., Powell, J.T., et al. L-serine: A naturally-occurring amino acid with therapeutic potential. Neurotox. Res. 33(1), 213-221 (2018).