An internal standard for the quantification of L-asparagine
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Unlabeled Version(s)
35022L-Asparagine 34519L-Asparagine (hydrate)
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L-Asparagine-d3 (hydrate)

Item No. 34835

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-asparagine-2,3,3-d3, monohydrate
CAS Number
2483831-59-8
Molecular Formula
C4H5D3N2O3 • H2O
Formula Weight
153.2
Purity
≥99% deuterated forms (d1-d3)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
1N HCl: soluble
SMILES
N[C@](C([2H])([2H])C(N)=O)([2H])C(O)=O.O
InChi Code
InChI=1S/C4H8N2O3.H2O/c5-2(4(8)9)1-3(6)7;/h2H,1,5H2,(H2,6,7)(H,8,9);1H2/t2-;/m0./s1/i1D2,2D;
InChi Key
RBMGJIZCEWRQES-HWSDRXMZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $41

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    5 mg

    $186

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    10 mg

    $293

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    Product Description

    L-Asparagine-d3 is intended for use as an internal standard for the quantification of L-asparagine (Item No. 34519) by GC- or LC-MS. L-Asparagine is a non-essential amino acid.1 It is formed from L-aspartic acid and L-glutamine (Item No. 23716) by asparagine synthetase (ASNS), and it is deamidated by L-asparaginase to produce L-aspartic acid and ammonia.2,3 L-Asparagine (0.3 mM) reverses ASNS siRNA knockdown-induced decreases in proliferation in a panel of six human cancer cell lines, indicating that both exogenous and endogenous L-asparagine promote proliferation of these cells.4 Formulations containing L-asparagine have been used as dietary supplements.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chiu, M.I., Taurino, G., Bianchi, M.G., et al. Asparagine synthetase in cancer: Beyond acute lymphoblastic leukemia. Front. Oncol. 9, 1480 (2020).

    2. Zhu, W., Radadiya, A., Bisson, C., et al. High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity. Commun. Biol. 2, 345 (2019).

    3. Covini, D., Tardito, S., Bussolati, O., et al. Expanding targets for a metabolic therapy of cancer: L-Asparaginase. Recent Pat. Anticancer Drug Discov. 7(1), 4-13 (2012).

    4. Pathria, G., Lee, J.S., Hasnis, E., et al. Translational reprogramming marks adaptation to asparagine restriction in cancer. Nat. Cell Biol. 21(12), 1590-1603 (2019).