L-Glutamine-d₅

L-Glutamine-d₅ is intended for use as an internal standard for the quantification of L-glutamine (Item No. 23716) by GC- or LC-MS. L-Glutamine is a conditionally essential amino acid involved in many biochemical processes. It is synthesized in vivo by glutamate and ammonia.¹ It serves as a substrate for glutamine synthetase in neurons for the biosynthesis of the major excitatory and inhibitory neurotransmitters glutamate and GABA.² L-Glutamine decreases adhesion of sickle red blood cells (RBCs) to human umbilical vein endothelial cells (HUVECs) when incubated ex vivo with patient-derived autologous plasma either alone or with LPS.³ It has commonly been used in cell culture media. Formulations containing L-glutamine have been used in the treatment of sickle cell disease.

WARNING This product is not for human or veterinary use.

1. Eisenberg, D., Gill, H.S., Pfluegl, G.M.U., et al. Structure-function relationships of glutamine synthetases. Biochim. Biophys. Acta 1477(1-2), 122-145 (2000).

2. Bak, L.K., Schousboe, A., and Waagepetersen, H.S. The glutamate/GABA-glutamine cycle: Aspects of transport, neurotransmitter homeostasis and ammonia transfer. J. Neurochem. 98(3), 641-653 (2006).

3. Niihara, Y., Matsui, N.M., Shen, Y.M., et al. L-glutamine therapy reduces endothelial adhesion of sickle red blood cells to human umbilical vein endothelial cells. BMC Blood Disord. 5(4), (2005).