An active metabolite of spironolactone
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7α-Thiospironolactone

Item No. 34868

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
17α-hydroxy-7α-mercapto-3-oxo-pregn-4-ene-21-carboxylic acid, γ-lactone
CAS Number
38753-76-3
Synonyms
  • Deacetylspironolactone
  • Mercaptospironolactone
  • SC-24813
  • 7α-Thio-SL
Molecular Formula
C22H30O3S
Formula Weight
374.5
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble
λmax
237 nm
SMILES
C[C@@]12[C@@]3(OC(CC3)=O)CC[C@@]1([H])[C@@]4([H])[C@]([C@@]5(C(C[C@H]4S)=CC(CC5)=O)C)([H])CC2
InChi Code
InChI=1S/C22H30O3S/c1-20-7-3-14(23)11-13(20)12-17(26)19-15(20)4-8-21(2)16(19)5-9-22(21)10-6-18(24)25-22/h11,15-17,19,26H,3-10,12H2,1-2H3/t15-,16-,17+,19+,20-,21-,22+/m0/s1
InChi Key
NZCDWYJROUPYPT-NYTLBARGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    1 mg

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    5 mg

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    10 mg

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    Product Description

    7α-Thiospironolactone (7α-Thio-SL) is an active metabolite of the synthetic steroid spironolactone.1 In vivo, 7α-thio-SL (100 mg/kg) decreases plasma testosterone and estradiol levels in male dogs.2 It reduces mercuric chloride-induced nephrocalcinosis and mortality in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Los, L.E., Coddington, A.B., Ramjit, H.G., et al. Identification of spironolactone metabolites in plasma and target organs of guinea pigs. Drug Metab. Dispos. 21(6), 1086-1090 (1993).

    2. Menard, R.H., Loriaux, D.L., Bartter, F.C., et al. The effect of the administration of spironolactone on the concentration of plasma testosterone, estradiol and cortisol in male dogs. Steroids 31(6), 771-782 (1978).

    3. Szabo, S., and Gagnon, M.J. The protective effect of sulfur-containing steroids against nephrocalcinosis induced by mercuric chloride in rats. Gen. Pharmacol. 14(2), 269-272 (1983).