An SHP-1 activator
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

SC-43

Item No. 34874

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-chloro-3-(trifluoromethyl)phenyl]-N′-[3-(4-cyanophenoxy)phenyl]-urea
CAS Number
1400989-25-4
Molecular Formula
C21H13ClF3N3O2
Formula Weight
431.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 15 mg/ml
λmax
265 nm
SMILES
N#CC1=CC=C(C=C1)OC2=CC=CC(NC(NC3=CC=C(C(C(F)(F)F)=C3)Cl)=O)=C2
InChi Code
InChI=1S/C21H13ClF3N3O2/c22-19-9-6-15(11-18(19)21(23,24)25)28-20(29)27-14-2-1-3-17(10-14)30-16-7-4-13(12-26)5-8-16/h1-11H,(H2,27,28,29)
InChi Key
QIBWSQJZKMUZAK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $64

    Add

    5 mg

    $256

    Add

    10 mg

    $383

    Add

    25 mg

    $638

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    SC-43 is an activator of Src homology region 2 domain-containing phosphatase 1 (SHP-1).1 It activates SHP-1 phosphatase activity in a cell-free assay and inhibits IL-6-induced phosphorylation of STAT3 in PLC/PRF/5 hepatocellular carcinoma cells when used at a concentration of 10 µM. SC-43 inhibits the proliferation of PLC/PRF/5 cells (IC50 = 0.5 µM). It decreases disease severity and improves survival in a mouse model of carbon tetrachloride-induced liver fibrosis when administered at doses of 10 and 20 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, K.-F., Tai, W.-T., Hsu, C.-Y., et al. Blockade of STAT3 activation by sorafenib derivatives through enhancing SHP-1 phosphatase activity. Eur. J. Med. Chem. 55, 220-227 (2012).

    2. Su, T.-H., Shiau, C.-W., Jao, P., et al. Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosis. Sci. Rep. 7(1), 1728 (2017).