An IDO1 inhibitor
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IDO-IN-2

Item No. 34876

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[bis(2-methylpropyl)amino]-2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-3-yl]-N′-(4-methylphenyl)-urea
CAS Number
1668565-74-9
Synonyms
  • PCC0208009
Molecular Formula
C29H35N7O
Formula Weight
497.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 2 mg/mlPBS (pH 7.2): insol
λmax
257 nm
SMILES
O=C(NC1=C(N(CC(C)C)CC(C)C)C=CC(C2=C(C3=NN=NN3)C=CC=C2)=C1)NC4=CC=C(C)C=C4
InChi Code
InChI=1S/C29H35N7O/c1-19(2)17-36(18-20(3)4)27-15-12-22(24-8-6-7-9-25(24)28-32-34-35-33-28)16-26(27)31-29(37)30-23-13-10-21(5)11-14-23/h6-16,19-20H,17-18H2,1-5H3,(H2,30,31,37)(H,32,33,34,35)
InChi Key
CJNMMPAEIYFQIJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    IDO-IN-2 is an inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1; IC50 = 0.097 µM in HeLa cells).1 In vivo, IDO-IN-2 (100 mg/kg) decreases intratumor levels of Ki67, a marker of cell proliferation, and reduces tumor weight in a GL261 murine glioma heterotopic transplantation model.2 It also decreases mechanical and thermal hypersensitivity, improves novel object recognition, and decreases anterior cingulate cortex (ACC) and amygdala levels of IDO1 in a rat model of neuropathic pain induced by spinal nerve ligation (SNL).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Williams, D.K., Markwalder, J.A., Balog, A.J., et al. Development of a series of novel o-phenylenediamine-based indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. Bioorg. Med. Chem. Lett. 28(4), 732-736 (2018).

    2. Sun, S., Du, G., Xue, J., et al. PCC0208009 enhances the anti-tumor effects of temozolomide through direct inhibition and transcriptional regulation of indoleamine 2,3-dioxygenase in glioma models. Int. J. Immunopathol. Pharmacol. 32, 2058738418787991 (2018).

    3. Wang, Y., Li, C.-M., Han, R., et al. PCC0208009, an indirect IDO1 inhibitor, alleviates neuropathic pain and co-morbidities by regulating synaptic plasticity of ACC and amygdala. Biochem. Pharmacol. 177, 113926 (2020).