A tubulin polymerization inhibitor and tumor vascular disrupting agent
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Ombrabulin (hydrochloride)

Item No. 34897

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-3-hydroxy-N-[2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl]-propanamide, monohydrochloride
CAS Number
253426-24-3
Synonyms
  • AC-7700
  • AVE-8062
  • CS 39-L-Ser
Molecular Formula
C21H26N2O6 • HCl
Formula Weight
438.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: soluble
λmax
292 nm
SMILES
COC1=C(C=C(C=C1OC)/C=C\C2=CC(NC([C@@H](N)CO)=O)=C(C=C2)OC)OC.Cl
InChi Code
InChI=1S/C21H26N2O6.ClH/c1-26-17-8-7-13(9-16(17)23-21(25)15(22)12-24)5-6-14-10-18(27-2)20(29-4)19(11-14)28-3;/h5-11,15,24H,12,22H2,1-4H3,(H,23,25);1H/b6-5-;/t15-;/m0./s1
InChi Key
UQNRTPFLTRZEIM-MRWUDIQNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $36

    Add

    5 mg

    $128

    Add

    10 mg

    $236

    Add

    25 mg

    $502

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Ombrabulin is a tubulin polymerization inhibitor (IC50 = 11.3 µM) and tumor vascular disrupting agent.1,2 It induces cell cycle arrest at the G2/M phase and apoptosis in HEY A8 ovarian cancer and mouse mesenteric endothelial cells.2 Ombrabulin (30 mg/kg) reduces tumor growth and induces tumor necrosis in a HEY A8 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Monk, K., Siles, R., Hadimani, M.B., et al. Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents. Bioorg. Med. Chem. 14(9), 3231-3244 (2006).

    2. Kim, T.J., Ravoori, M., Landen, C.N., et al. Antitumor and antivascular effects of AVE8062 in ovarian carcinoma. Cancer Res. 67(19), 9337-9345 (2007).