A potential impurity found in commercial preparations of ramipril
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Ramipril Diketopiperazine

Item No. 34917

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αS,3S,5aS,8aS,9aS)-decahydro-3-methyl-1,4-dioxo-α-(2-phenylethyl)-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazine-2-acetic acid, ethyl ester
CAS Number
108731-95-9
Molecular Formula
C23H30N2O4
Formula Weight
398.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: soluble
SMILES
O=C1N2[C@](C[C@@]3([H])[C@]2([H])CCC3)([H])C(N([C@H]1C)[C@H](C(OCC)=O)CCC4=CC=CC=C4)=O
InChi Code
InChI=1S/C23H30N2O4/c1-3-29-23(28)19(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-18-11-7-10-17(18)14-20(25)22(24)27/h4-6,8-9,15,17-20H,3,7,10-14H2,1-2H3/t15-,17-,18-,19-,20-/m0/s1
InChi Key
KOVMAAYRBJCASY-JBDAPHQKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Ramipril diketopiperazine is a potential impurity found in commercial preparations of ramipril.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Orlandini, S., Gotti, R., Giannini, I., et al. Development of a capillary electrophoresis method for the assay of ramipril and its impurities: An issue of cis-trans isomerization. J. Chromatogr. A 1218(18), 2611-2617 (2011).