CD1d Monoclonal Antibody (Clone 59G)

CD1d is a lipid antigen-presenting molecule and a member of the group II CD1 family expressed by humans and mice.¹ It is composed of a heavy chain, a transmembrane region, and a short intracellular C-terminal tail.¹ The heavy chain contains three extracellular domains that associate with the light-chain β2-microglobulin. It is expressed primarily by antigen-presenting cells.^1,2 CD1d is directly involved in the process of presenting lipid antigens to T cells and invariant natural killer T (iNKT) cells to induce an immune response, including the secretion of specific cytokines depending on the antigen presented. Activation of iNKT cells by CD1d presentation of α-galactosylceramide (α-GalCer) in a murine model of melanoma reduces the number of metastases, but only when bone marrow-derived dendritic cells (BMDCs) were used to prolong iNKT cell responses.³ Cayman's CD1d Monoclonal Antibody (Clone 59G) can be used for ELISA, flow cytometry (FC), and Western blot (WB) applications. The antibody recognizes CD1d at approximately 52 kDa from human samples.

WARNING This product is not for human or veterinary use.

1. Florence, W.C., Bhat, R.K., and Joyce, S. CD1d-restricted glycolipid antigens: Presentation principles, recognition logic and functional consequences. Expert. Rev. Mol. Med. 10, e20 (2008).

2. Joyce, S. CD1d and natural T cells: How their properties jump-start the immune system. Cell Mol. Life Sci. 58(3), 442-469 (2001).

3. Wen, X., Rao, P., Carreño, L.J., et al. Human CD1d knock-in mouse model demonstrates potent antitumor potential of human CD1d-restricted invariant natural killer T cells. Proc. Natl. Acad. Sci. USA 110(8), 2963-2968 (2013).