A derivative of EPO
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ARA 290 (acetate)

Item No. 34943

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-oxo-L-prolyl-L-α-glutamyl-L-glutaminyl-L-leucyl-L-α-glutamyl-L-arginyl-L-alanyl-L-leucyl-L-asparaginyl-L-seryl-L-serine, acetate
Synonyms
  • Cibinetide
  • PHBSP
  • Pyroglutamate HBSP
  • Pyroglutamate Helix B Surface Peptide
Molecular Formula
C51H84N16O21 • XC2H4O2
Formula Weight
1257.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/ml
SMILES
OC([C@H](CO)NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H](CCC(N)=O)NC([C@H](CCC(O)=O)NC([C@@H]1CCC(N1)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.CC(O)=O
InChi Code
InChI=1S/C51H84N16O21.C2H4O2/c1-22(2)17-30(47(84)65-32(19-36(53)71)48(85)66-33(20-68)49(86)67-34(21-69)50(87)88)63-40(77)24(5)57-41(78)25(7-6-16-56-51(54)55)59-43(80)29(11-15-39(75)76)62-46(83)31(18-23(3)4)64-45(82)27(8-12-35(52)70)60-44(81)28(10-14-38(73)74)61-42(79)26-9-13-37(72)58-26;1-2(3)4/h22-34,68-69H,6-21H2,1-5H3,(H2,52,70)(H2,53,71)(H,57,78)(H,58,72)(H,59,80)(H,60,81)(H,61,79)(H,62,83)(H,63,77)(H,64,82)(H,65,84)(H,66,85)(H,67,86)(H,73,74)(H,75,76)(H,87,88)(H4,54,55,56);1H3,(H,3,4)/t24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-;/m0./s1
InChi Key
AHEDJRSNELUIJJ-WVTOCIHHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $49

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    5 mg

    $213

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    10 mg

    $376

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    Product Description

    ARA 290 is a derivative of erythropoietin (EPO).1 In vivo, ARA 290 (0.8 and 8 nmol/kg, i.p.) reduces plasma creatine, urea, and aspartate aminotransferase (AST) levels, markers of renal dysfunction, in a rodent model of renal ischemia-reperfusion injury. It decreases wound area in a rat model of punch biopsy-induced dermal injury and a rat model of decubitus ulcer.2 ARA 290 (30 µg/kg, i.p.) reduces the latency to find the platform in the Morris water maze in a rat model of cortical impact-induced traumatic brain injury (TBI).3 It also reduces tactile allodynia in a rat model of neuropathic pain induced by spinal nerve injury (SNI).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brines, M., Patel, N.S.A., Villa, P., et al. Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin. Proc. Natl. Acad. Sci. USA 105(31), 10925-10930 (2008).

    2. Erbayraktar, Z., Erbayraktar, S., Yilmaz, O., et al. Nonerythropoietic tissue protective compounds are highly effective facilitators of wound healing. Mol. Med. 15(7-8), 235-241 (2009).

    3. Robertson, C.S., Garcia, R., Gaddam, S.S.K., et al. Treatment of mild traumatic brain injury with an erythropoietin-mimetic peptide. J. Neurotrauma 30(9), 765-774 (2013).

    4. Swartjes, M., Niesters, M., and Dahan, A. Assessment of allodynia relief by tissue-protective molecules in a rat model of nerve injury-induced neuropathic pain. Methods Mol. Biol. 982, 187-195 (2013).