A chromogenic substrate for thrombin
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S-2238 (hydrochloride)

Item No. 34944

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
D-phenylalanyl-(2S)-2-piperidinecarbonyl-N-(4-nitrophenyl)-L-argininamide, monohydrochloride
CAS Number
160192-34-7
Synonyms
  • H-D-Phe-Pip-Arg-pNA
  • D-Phe-Piperidinecarbonyl-Arg-p-nitroanilide
Molecular Formula
C27H36N8O5 • HCl
Formula Weight
589.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
313 nm
SMILES
O=N(C(C=C1)=CC=C1NC([C@H](CCCNC(N)=N)NC([C@H]2N(CCCC2)C([C@H](N)CC3=CC=CC=C3)=O)=O)=O)=O.Cl
InChi Code
InChI=1S/C27H36N8O5.ClH/c28-21(17-18-7-2-1-3-8-18)26(38)34-16-5-4-10-23(34)25(37)33-22(9-6-15-31-27(29)30)24(36)32-19-11-13-20(14-12-19)35(39)40;/h1-3,7-8,11-14,21-23H,4-6,9-10,15-17,28H2,(H,32,36)(H,33,37)(H4,29,30,31);1H/t21-,22+,23+;/m1./s1
InChi Key
YEOVJZRYPLLHJL-FMVQVTEISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    S-2238 is a chromogenic substrate for thrombin.1,2 Upon enzymatic cleavage, p-nitroanilide (pNA) is released which can be quantified by colorimetric detection at 405 nm as a measure of thrombin activity.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Abildgaard, U., Lie, M., and Ødegȧrd, O.R. Antithrombin (heparin cofactor) assay with "new" chromogenic substrates (S-2238 and Chromozym TH). Thromb. Res. 11(4), 549-553 (1977).

    2. Ohno, H., Kosaki, G., Kambayashi, J., et al. FOY: [ethyl P-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine proteinase inhibitor. I. Inhibition of thrombin and factor Xa in vitro. Thromb. Res. 19(4-5), 579-588 (1980).