A cyclic pentapeptide
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cyclo(RGDyC) (trifluoroacetate salt)

Item No. 34945

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-((2S,5R,8R,11S)-11-(3-guanidinopropyl)-5-(4-hydroxybenzyl)-8-(mercaptomethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid, trifluoroacetate salt
Synonyms
  • c(RGDyC)
  • cyclo(Arg-Gly-Asp-D-Tyr-Cys)
Molecular Formula
C24H34N8O8S • XCF3COOH
Formula Weight
594.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: soluble
SMILES
O=C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N1)=O)CC(O)=O)=O)=O)CCCNC(N)=N)=O)CS)[C@H]1CC2=CC=C(C=C2)O.FC(F)(F)C(O)=O
InChi Code
InChI=1S/C24H34N8O8S.C2HF3O2/c25-24(26)27-7-1-2-14-20(37)28-10-18(34)29-16(9-19(35)36)22(39)31-15(8-12-3-5-13(33)6-4-12)21(38)32-17(11-41)23(40)30-14;3-2(4,5)1(6)7/h3-6,14-17,33,41H,1-2,7-11H2,(H,28,37)(H,29,34)(H,30,40)(H,31,39)(H,32,38)(H,35,36)(H4,25,26,27);(H,6,7)/t14-,15+,16-,17-;/m0./s1
InChi Key
AZBISXDKFNGVPV-ZSXFUQLHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $128

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    10 mg

    $235

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    25 mg

    $534

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    Product Description

    cyclo(RGDyC) is a cyclic pentapeptide that contains the αVβ3 integrin-binding sequence arginine-glycine-aspartate (RGD).1,2 It has been used to generate doxorubicin-containing liposomes and fluorescent silicon nanoparticles to target tumors and ocular neovasculature, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Amin, A., Mansourian, M., Koning, G.A., et al. Development of a novel cyclic RGD peptide for multiple targeting approaches of liposomes to tumor region. J. Control Release 220(Pt A), 308-315 (2015).

    2. Tang, M., Ji, X., Xu, H., et al. Photostable and biocompatible fluorescent silicon nanoparticles-based theranostic probes for simultaneous imaging and treatment of ocular neovascularization. Anal. Chem. 90(13), 8188-8195 (2018).