A vitamin K antagonist
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Fluindione

Item No. 34966

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(4-fluorophenyl)-1H-indene-1,3(2H)-dione
CAS Number
957-56-2
Molecular Formula
C15H9FO2
Formula Weight
240.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: insolDMSO: 1 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): insol
λmax
223, 267 nm
SMILES
O=C1C2=C(C(C1C3=CC=C(C=C3)F)=O)C=CC=C2
InChi Code
InChI=1S/C15H9FO2/c16-10-7-5-9(6-8-10)13-14(17)11-3-1-2-4-12(11)15(13)18/h1-8,13H
InChi Key
NASXCEITKQITLD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $49

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    10 mg

    $93

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    25 mg

    $206

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    50 mg

    $387

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    Product Description

    Fluindione is a vitamin K antagonist.1 It inhibits vitamin K epoxide reductase (VKOR; IC50 = 6.6 nM), including VKOR containing certain substitution mutations. Fluindione inhibits platelet and fibrin deposition, as well as prevents β-thromboglobulin release and thrombin-antithrombin complex formation, in an ex vivo model of tissue factor-induced thrombus formation using isolated human whole blood.2 Fluindione has previously been used in the treatment of emboligenic heart disease, deep vein thrombosis, pulmonary embolism, and in the prevention of thromboembolic complications in patients with heart disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, X., Jin, D.-Y., Stafford, D.W., et al. Evaluation of oral anticoagulants with vitamin K epoxide reductase in its native milieu. Blood 132(18), 1974-1984 (2018).

    2. Bossavy, J.P., Sakariassen, K.S., Thalamas, C., et al. Antithrombotic efficacy of the vitamin K antagonist fluindione in a human ex vivo model of arterial thrombosis: Effect of anticoagulation level and combination therapy with aspirin. Arterioscler. Thromb. Vasc. Biol. 19(9), 2269-2275 (1999).