An SR-BI inhibitor
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BLT-1

Item No. 34989

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(2-hexylcyclopentylidene)-hydrazinecarbothioamide
CAS Number
321673-30-7
Synonyms
  • Block Lipid Transport-1
Molecular Formula
C12H23N3S
Formula Weight
241.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 11 mg/mlDMSO: 10 mg/mlEthanol: 5 mg/ml
λmax
273 nm
SMILES
S=C(NN=C1CCCC1CCCCCC)N
InChi Code
InChI=1S/C12H23N3S/c1-2-3-4-5-7-10-8-6-9-11(10)14-15-12(13)16/h10H,2-9H2,1H3,(H3,13,15,16)
InChi Key
OWGUSBISUVLUJF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $49

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    10 mg

    $87

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    25 mg

    $171

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    50 mg

    $291

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    Product Description

    BLT-1 is an inhibitor of scavenger receptor B1 (SR-BI).1 It inhibits uptake of [3H]cholesteryl ester-HDL in LDL receptor-deficient CHO cells expressing mouse SR-BI ((ldlA[mSR-BI]) cells; IC50 = 0.11 µM) and the efflux of cholesterol from ldlA[mSR-BI] cells to HDL (IC50 = 0.15 µM). BLT-1 (8 µM) induces developmental defects in zebrafish embryos, an effect that can be prevented by copper chloride.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nieland, T.J.F., Penman, M., Dori, L., et al. Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI. Proc. Natl. Acad. Sci. USA 99(24), 15422-15427 (2002).

    2. Raldúa, D., and Babin, P.J. BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish development. Toxicol. Lett. 175(1-3), 1-7 (2007).