A polyphenol with adipogenesis inhibitory and anticancer activities
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Agrimol B

Item No. 34996

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S)-1-[3,5-bis[[2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl]methyl]-2,4,6-trihydroxyphenyl]-2-methyl-1-butanone
CAS Number
55576-66-4
Molecular Formula
C37H46O12
Formula Weight
682.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mM
λmax
230, 288 nm
SMILES
OC(C(CC1=C(C(C(CCC)=O)=C(C(C)=C1O)OC)O)=C(C(C([C@@H](C)CC)=O)=C2O)O)=C2CC3=C(C(C(CCC)=O)=C(C(C)=C3O)OC)O
InChi Code
InChI=1S/C37H46O12/c1-9-12-23(38)25-32(44)19(29(41)17(5)36(25)48-7)14-21-31(43)22(35(47)27(34(21)46)28(40)16(4)11-3)15-20-30(42)18(6)37(49-8)26(33(20)45)24(39)13-10-2/h16,41-47H,9-15H2,1-8H3/t16-/m0/s1
InChi Key
BVLHMPZMQVWDGX-INIZCTEOSA-N
Origin
Plant/Agrimonia pilosa
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Agrimol B is a polyphenol that has been found in A. pilosa with adipogenesis inhibitory and anticancer activities.1,2 It induces nuclear translocation of sirtuin 1 (SIRT1) and reduces expression of peroxisome proliferator-activated receptor γ (PPARγ), C/EBPα, and fatty acid synthase (FASN) in 3T3-L1 adipocytes when used at a concentration of 10 µM. Agrimol B reduces lipid droplet accumulation in 3T3-L1 adipocytes (IC50 = 3.35 µM). It is cytotoxic to PC3 prostate and A549 lung cancer cells in vitro and reduces tumor volume in a PC3 mouse xenograft model when administered at a dose of 10 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, S., Zhang, Q., Zhang, Y., et al. Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway. Biochem. Biophys. Res. Commun. 477(3), 454-460 (2016).

    2. Hnit, S.S.T., Ding, R., Bi, L., et al. Agrimol B present in Agrimonia pilosa Ledeb impedes cell cycle progression of cancer cells through G0 state arrest. Biomed. Pharmacother. 141, 111795 (2021).