An inhibitor of MAO-B
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Mofegiline (hydrochloride)

Item No. 35010

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-fluoro-βE-(fluoromethylene)-benzenebutanamine, monohydrochloride
CAS Number
120635-25-8
Synonyms
  • MDL 72974A
Molecular Formula
C11H13F2N • HCl
Formula Weight
233.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 30 mg/ml
SMILES
F/C=C(CN)\CCC1=CC=C(C=C1)F.Cl
InChi Code
InChI=1S/C11H13F2N.ClH/c12-7-10(8-14)2-1-9-3-5-11(13)6-4-9;/h3-7H,1-2,8,14H2;1H/b10-7+;
InChi Key
QUCNNQHLIHGBIA-HCUGZAAXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $168

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    50 mg

    $318

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    Product Description

    Mofegiline is an inhibitor of monoamine oxidase B (MAO-B; IC50 = 3.6 nM for the rat brain mitochondrial enzyme).1 It is selective for MAO-B over MAO-A (IC50 = 680 nM). Mofegiline also inhibits vascular adhesion protein-1 (VAP-1), also known as semicarbazide-sensitive amine oxidase (SSAO), an enzyme that has roles in leukocyte adhesion and transmigration, with an IC50 value of 20 nM for the human enzyme.2 It reduces MPTP-induced decreases in striatal levels of dopamine, dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) in mice when administered at a dose of 1.25 mg/kg.1 Mofegiline (5 mg/kg) also inhibits LPS-induced increases in bronchoalveolar lavage fluid (BALF) levels of TNF-α in transgenic mice overexpressing VAP-1.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zreika, M., Fozard, J.R., Dudley, M.W., et al. MDL 72,974: A potent and selective enzyme-activated irreversible inhibitor of monoamine oxidase type B with potential for use in Parkinson’s disease. J. Neural Transm. Park. Dis. Dement. Sect. 1(4), 243-254 (1989).

    2. Foot, J.S., Deodhar, M., Turner, C.I., et al. The discovery and development of selective 3-fluoro-4-aryloxyallylamine inhibitors of the amine oxidase activity of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1). Bioorg. Med. Chem. Lett. 22(12), 3935-3940 (2012).