A contrast reagent
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Iodixanol

Item No. 35020

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,5′-[(2-hydroxy-1,3-propanediyl)bis(acetylimino)]bis[N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide
CAS Number
92339-11-2
Molecular Formula
C35H44I6N6O15
Formula Weight
1550.2
Purity
≥95% (mixture of isomers)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 15 mg/mlEthanol: insolPBS (pH 7.2): 10 mg/ml
λmax
246 nm
SMILES
O=C(C1=C(I)C(N(CC(CN(C2=C(I)C(C(NCC(CO)O)=O)=C(I)C(C(NCC(CO)O)=O)=C2I)C(C)=O)O)C(C)=O)=C(I)C(C(NCC(CO)O)=O)=C1I)NCC(CO)O
InChi Code
InChI=1S/C35H44I6N6O15/c1-13(52)46(30-26(38)20(32(59)42-3-15(54)9-48)24(36)21(27(30)39)33(60)43-4-16(55)10-49)7-19(58)8-47(14(2)53)31-28(40)22(34(61)44-5-17(56)11-50)25(37)23(29(31)41)35(62)45-6-18(57)12-51/h15-19,48-51,54-58H,3-12H2,1-2H3,(H,42,59)(H,43,60)(H,44,61)(H,45,62)
InChi Key
NBQNWMBBSKPBAY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $118

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    10 mg

    $172

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    25 mg

    $388

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    Product Description

    Iodixanol is a nonionic, water-soluble contrast reagent.1 It induces apoptosis and mitophagy in renal epithelial cells in a rat model of contrast-induced acute kidney injury.2 Iodixanol has also been used as a density gradient medium in the fractionation of plasma lipoproteins.3 Formulations containing iodixanol have been used for the visualization of arteries, veins, the urinary tract, head, and body using X-ray and computed tomography (CT) scan imaging techniques.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Almén, T. Visipaque - a step forward: A historical review. Acta Radiol. 57(5), e47-e63 (1995).

    2. Cheng, W., Zhao, F., Tang, C.-Y., et al. Comparison of iohexol and iodixanol induced nephrotoxicity, mitochondrial damage and mitophagy in a new contrast-induced acute kidney injury rat model. Arch. Toxicol. 92(7), 2245-2257 (2018).

    3. Graham, J.M., Higgins, J.A., Gillott, T., et al. A novel method for the rapid separation of plasma lipoproteins using self-generating gradients of iodixanol. Atherosclerosis 124(1), 125-135 (1996).