A PU.1 inhibitor
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DB2313 (hydrochloride)

Item No. 35021

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2′-[(2-fluoro-1,3-phenylene)bis(methyleneoxy-4,1-phenylene)]bis[N-(1-methylethyl)-1H-benzimidazole-6-carboximidamide, hydrochloride
Molecular Formula
C42H41FN8O2 • XHCl
Formula Weight
708.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
223, 264, 316 nm
SMILES
FC1=C(COC2=CC=C(C3=NC4=CC=C(C(NC(C)C)=N)C=C4N3)C=C2)C=CC=C1COC5=CC=C(C6=NC7=CC=C(C(NC(C)C)=N)C=C7N6)C=C5.Cl
InChi Code
InChI=1S/C42H41FN8O2.ClH/c1-24(2)46-39(44)28-12-18-34-36(20-28)50-41(48-34)26-8-14-32(15-9-26)52-22-30-6-5-7-31(38(30)43)23-53-33-16-10-27(11-17-33)42-49-35-19-13-29(21-37(35)51-42)40(45)47-25(3)4;/h5-21,24-25H,22-23H2,1-4H3,(H2,44,46)(H2,45,47)(H,48,50)(H,49,51);1H
InChi Key
GCCVHRQDJGHJEI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $145

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    10 mg

    $256

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    Cayman Chemical
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    Product Description

    DB2313 is an inhibitor of the transcription factor PU.1 (IC50 = 14 nM).1 Long-term exposure of DB2313 (300 nM) to Kit+/Sca-1+/Lin- hematopoietic stem progenitor cells (KSL-HSPCs) reduces colony formation. DB2313 (700 nM) decreases ovalbumin-induced reprogramming of isolated mouse neutrophils into antigen-presenting cells.2 It decreases tumor growth, weight, and volume in a U87MG glioblastoma multiforme mouse xenograft model when administered at a dose of 10 mg/kg per day.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Antony-Debré, I., Paul, A., Leite, J., et al. Pharmacological inhibition of the transcription factor PU.1 in leukemia. J. Clin. Invest. 127(12), 4297-4313 (2017).

    2. Mysore, V., Cullere, X., Mears, J., et al. FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity. Nat. Commun. 12(1), 4791 (2021).

    3. Zhang, S., Zhao, S., Qi, Y., et al. SPI1-induced downregulation of FTO promotes GBM progression by regulating pri-miR-10a processing in an m6A-dependent manner. Mol. Ther. Nucleic Acids 27, 699-717 (2022).