An ionizable cationic and biodegradable lipid derivative of DLin-MC3-DMA
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L-319

Item No. 35051

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-[4-(dimethylamino)-1-oxobutoxy]-heptadecanedioic acid, 1,17-di-(2Z)-2-nonen-1-yl ester
CAS Number
1351586-50-9
Molecular Formula
C41H75NO6
Formula Weight
678.0
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleEthanol: Soluble
SMILES
CN(C)CCCC(OC(CCCCCCCC(OC/C=C\CCCCCC)=O)CCCCCCCC(OC/C=C\CCCCCC)=O)=O
InChi Code
InChI=1S/C41H75NO6/c1-5-7-9-11-13-21-27-36-46-39(43)32-25-19-15-17-23-30-38(48-41(45)34-29-35-42(3)4)31-24-18-16-20-26-33-40(44)47-37-28-22-14-12-10-8-6-2/h21-22,27-28,38H,5-20,23-26,29-37H2,1-4H3/b27-21-,28-22-
InChi Key
DGNMJYUPWDTKJB-ZDSKVHJSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $89

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    10 mg

    $116

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    25 mg

    $223

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    50 mg

    $401

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    Product Description

    L-319 is an ionizable cationic (pKa = 6.38) and biodegradable lipid derivative of DLin-MC3-DMA (Item No. 34364) that has been used in the formation of lipid nanoparticles (LNPs).1 LNPs containing L-319 and encapsulating siRNA encoding Factor VII (FVII) reduce serum levels of FVII in mice. LNPs containing L-319 in combination with cKK-E12 (Item No. 36700) and encapsulating varicella-zoster virus (VZV) mRNA encoding glycoprotein E (gE) increase the lymph node and spleen levels of CD11c+CD80+ and CD11c+CD86+ cells and total serum IgG titers in mice, as well as decrease the number of VZV-induced rashes and the epithelial levels of VZV DNA, in a guinea pig model of VZV-induced shingles.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Maier, M.A., M., J., Matsuda, S., et al. Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics. Mol. Ther. 21(8), 1570-1578 (2013).

    2. Cheng, X., Liu, S., Sun, J., et al. A synergistic lipid nanoparticle encapsulating mRNA shingles vaccine induces potent immune responses and protects guinea pigs from viral challenges. Adv. Mat. 36(13), e2310886 (2023).