An internal standard for the quantification of flunixin
Related Products
Unlabeled Version(s)
26644Flunixin (meglumine)
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Flunixin-d3

Item No. 35056

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[2-(methyl-d3)-3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid
CAS Number
1015856-60-6
Molecular Formula
C14H8D3F3N2O2
Formula Weight
299.3
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
OC(C(C=CC=N1)=C1NC2=C(C(C(F)(F)F)=CC=C2)C([2H])([2H])[2H])=O
InChi Code
InChI=1S/C14H11F3N2O2/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12/h2-7H,1H3,(H,18,19)(H,20,21)/i1D3
InChi Key
NOOCSNJCXJYGPE-FIBGUPNXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $32

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    5 mg

    $148

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    10 mg

    $264

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    Product Description

    Flunixin-d3 is intended for use as an internal standard for the quantification of flunixin (Item No. 26644) by GC- or LC-MS. Flunixin is a non-steroidal anti-inflammatory drug (NSAID) that inhibits COX-1 and COX-2 (IC50s = 3.24 and 0.55 µM, respectively).1 It inhibits carrageenan-induced prostaglandin E2 (PGE2; Item No. 14010) and thromboxane B2 (TXB2; Item No. 19030) production in sheep exudate and serum, respectively, when administered at a dose of 1.1 mg/kg.2 Flunixin (1.1 mg/L per kg) has anti-inflammatory, analgesic, and antipyretic activity in horses.3 Formulations containing flunixin have been used in the veterinary treatment of pain and fever in livestock.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bryant, C.E., Farnfield, B.A., and Janicke, H.J. Evaluation of the ability of carprofen and flunixin meglumine to inhibit activation of nuclear factor kappa B. Am. J. Vet. Res. 64(2), 211-215 (2003).

    2. Cheng, Z., Nolan, A.M., and McKellar, Q.A. Measurement of cyclooxygenase inhibition in vivo: A study of two non-steroidal anti-inflammatory drugs in sheep. Inflammation 22(4), 353-366 (1998).

    3. Houdeshell, J.W., and Hennessey, P.W. A new nonsteroidal, anti-inflammatory analgesic for horses. J. Equine Vet Sci. 1(2), 57-63 (1977).