An internal standard for the quantification of lidocaine
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Lidocaine-d10

Item No. 35066

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[di(ethyl-d5)amino]-N-(2,6-dimethylphenyl)-acetamide
CAS Number
851528-09-1
Molecular Formula
C14H12D10N2O
Formula Weight
244.4
Purity
≥99% deuterated forms (d1-d10)
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
[2H]C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C([2H])([2H])[2H])CC(N(C1=C(C)C=CC=C1C)[H])=O
InChi Code
InChI=1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)/i1D3,2D3,5D2,6D2
InChi Key
NNJVILVZKWQKPM-JKSUIMTKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $44

    Add

    5 mg

    $142

    Add

    10 mg

    $260

    Add
    Product Description

    Lidocaine-d10 is intended for use as an internal standard for the quantification of lidocaine by GC- or LC-MS. Lidocaine is an inhibitor of voltage-gated sodium channels (Navs) and a local anesthetic.1,2,3 It inhibits Nav1.2 (Ki = 11 µM), adult and neonatal Nav1.5 (IC50s = 380.1 and 360 µM, respectively), and Nav1.7 and Nav1.8 channels (IC50s = 450 and 104 µM, respectively) expressed in Xenopus oocytes. Topical administration of lidocaine (1-2%) reduces escape behavior in a rhesus monkey model of noxious electrical cutaneous pain.4 Formulations containing lidocaine have been used as local and regional anesthetics.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ragsdale, D.S., McPhee, J.C., Scheuer, T., et al. Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels. Proc. Natl. Acad. Sci. USA 93(17), 9270-9275 (1996).

    2. Fraser, S.P., Onkal, R., Theys, M., et al. Neonatal Nav1.5 channels: Pharmacological distinctiveness of a cancer-related voltage-gated sodium channel splice variant. Br. J. Pharmacol. Online ahead of print, (2021).

    3. Chevrier, P., Vijayaragavan, K., and Chahine, M. Differential modulation of Nav1.7 and Nav1.8 peripheral nerve sodium channels by the local anesthetic lidocaine. Br. J. Pharmacol. 142(3), 576-584 (2004).

    4. Lineberry, C.G., and Kulics, A.T. The effects of diazepam, morphine and lidocaine on nociception in rhesus monkeys: A signal detection analysis. J. Pharmacol. Exp. Ther. 205(2), 302-310 (1978).