An active metabolite of sibutramine
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Desmethyl Sibutramine (hydrochloride)

Item No. 35073

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(4-chlorophenyl)-N-methyl-α-(2-methylpropyl)-cyclobutanemethanamine, monohydrochloride
CAS Number
84467-94-7
Synonyms
  • BTS-54354
Molecular Formula
C16H24ClN • HCl
Formula Weight
302.3
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: soluble
SMILES
ClC1=CC=C(C2(C(CC(C)C)NC)CCC2)C=C1.Cl
InChi Code
InChI=1S/C16H24ClN.ClH/c1-12(2)11-15(18-3)16(9-4-10-16)13-5-7-14(17)8-6-13;/h5-8,12,15,18H,4,9-11H2,1-3H3;1H
InChi Key
OUVFHVJVFLFXPQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $61

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    5 mg

    $208

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    10 mg

    $357

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    Product Description

    Desmethyl sibutramine is an active metabolite of sibutramine.1 It prevents reserpine-induced ptosis in rats (ED50 = 4.2 mg/kg) and decreases immobility in the Porsolt learned helplessness test in mice when administered at a dose of 10 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Luscombe, G.P., Hopcroft, R.H., Tomas, P.C., et al. The contribution of metabolites to the rapid and potent down-regulation of rat cortical β-adrenoceptors by the putative antidepressant sibutramine hydrochloride. Neuropharmacology 28(2), 129-134 (1989).