An NSAID and a prodrug form of loxoprofen-SRS
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Active Metabolite(s)
38122Loxoprofen-SRS
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Loxoprofen (sodium salt)

Item No. 35088

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-methyl-4-[(2-oxocyclopentyl)methyl]-benzeneacetic acid, monosodium salt
CAS Number
80382-23-6
Molecular Formula
C15H18O3 • Na
Formula Weight
269.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
223 nm
SMILES
O=C(C(C)C1=CC=C(CC2C(CCC2)=O)C=C1)O.[Na]
InChi Code
InChI=1S/C15H18O3.Na/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16;/h5-8,10,13H,2-4,9H2,1H3,(H,17,18);
InChi Key
IEPGDDWZDRJSIT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Loxoprofen is a non-steroidal anti-inflammatory drug (NSAID) and prodrug form of loxoprofen-SRS.1 It inhibits COX-1 and COX-2 in isolated human whole blood (IC50s = 6.5 and 13.5 µM, respectively). Loxoprofen reduces acetic acid-induced writhing in mice and carrageenan-induced paw edema and LPS-induced fever in rats (ED30s = 20.1, 0.7, and 2.79 mg/kg, respectively).2 Formulations containing loxoprofen have been used in the treatment of pain associated with osteoarthritis, myalgia, and post-traumatic swelling.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Riendeau, D., Salem, M., Styhler, A., et al. Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2. Bioorg. Med. Chem. Lett. 14(5), 1201-1203 (2004).

    2. Futaki, N., Yoshikawa, K., Hamasaka, Y., et al. NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen. Pharmacol. 24, 105-110 (1993).