A metabolite of p-cresol
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p-Cresol Glucuronide

Item No. 35113

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-methylphenyl β-D-glucopyranosiduronic acid
Synonyms
  • 4-Cresol Glucuronide
  • p-Tolyl-β-D-glucuronide
Molecular Formula
C13H16O7
Formula Weight
284.3
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: soluble
λmax
220 nm
SMILES
OC([C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC2=CC=C(C=C2)C)=O
InChi Code
InChI=1S/C13H16O7/c1-6-2-4-7(5-3-6)19-13-10(16)8(14)9(15)11(20-13)12(17)18/h2-5,8-11,13-16H,1H3,(H,17,18)/t8-,9-,10+,11-,13+/m0/s1
InChi Key
JPAUCQAJHLSMQW-XPORZQOISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $128

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    Product Description

    p-Cresol glucuronide is a metabolite of p-cresol, a uremic toxin formed by bacterial fermentation of proteins in the large intestine.1 It is formed from p-cresol primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT1A6, but also by UGT1A9, in human liver and kidney microsomes. p-Cresol glucuronide accumulates in feces, blood, and urine of patients with chronic kidney disease (CKD).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rong, Y., and Kiang, T.K.L. Characterizations of human UDP-glucuronosyltransferase enzymes in the conjugation of p-cresol. Toxicol. Sci. 176(2), 285-296 (2020).

    2. Gryp, T., De Paepe, K., Vanholder, R., et al. Gut microbiota generation of protein-bound uremic toxins and related metabolites is not altered at different stages of chronic kidney disease. Kidney Int. 97(6), 1230-1242 (2020).