A carotenoid with diverse biological activities
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Capsorubin

Item No. 35115

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3S,3′S,5R,5′R)-3,3′-dihydroxy-κ,κ-carotene-6,6′-dione
CAS Number
470-38-2
Molecular Formula
C40H56O4
Formula Weight
600.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: SolubleDMSO: Soluble
SMILES
O[C@@H]1C[C@](C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C([C@]2(C)C[C@@H](O)CC2(C)C)=O)=O)(C)C(C)(C)C1
InChi Code
InChI=1S/C40H56O4/c1-29(17-13-19-31(3)21-23-35(43)39(9)27-33(41)25-37(39,5)6)15-11-12-16-30(2)18-14-20-32(4)22-24-36(44)40(10)28-34(42)26-38(40,7)8/h11-24,33-34,41-42H,25-28H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,29-15+,30-16+,31-19+,32-20+/t33-,34-,39-,40-/m0/s1
InChi Key
GVOIABOMXKDDGU-YUURSNASSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $465

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    Product Description

    Capsorubin is a carotenoid that has been found in C. annuum and has diverse biological activities.1,2,3 It inhibits lipid peroxidation induced by 2,2’-azobis(2,4-dimethyl valeronitrile) (AMVN) in vitro when used at a concentration of 167 µM.1 Capsorubin (1 µM) decreases UVB-induced formation of DNA strand breaks and apoptosis in isolated human dermal fibroblasts.2 It also inhibits Epstein-Barr virus early antigen (EBV-EA) activation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014), a marker of tumor formation, in Raji cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Maoka, T., Goto, Y., Isobe, K., et al. Antioxidative activity of capsorubin and related compounds from paprika (Capsicum annuum). J. Oleo Sci. 50(8), 663-665 (2001).

    2. Fernández-García, E., Carvajal-Lérida, I., and Pérez-Gálvez, A. Carotenoids exclusively synthesized in red pepper (capsanthin and capsorubin) protect human dermal fibroblasts against UVB induced DNA damage. Photochem. Photobiol. Sci. 15(9), 1204-1211 (2016).

    3. Maoka, T., Mochida, K., Kozuka, M., et al. Cancer chemopreventive activity of carotenoids in the fruits of red paprika Capsicum annuum L. Cancer Lett. 172(2), 103-109 (2001).