A ruthenium complex with anticancer activity
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NKP-1339

Item No. 35123

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(OC-6-11)-tetrachlorobis(1H-indazole-κN2)-ruthenate(1-), monosodium salt
CAS Number
197723-00-5
Synonyms
  • KP1339
Molecular Formula
C14H12Cl4N4Ru • Na
Formula Weight
502.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: soluble
SMILES
[Cl-][Ru+3]([Cl-])([Cl-])([N]1=CC2=CC=CC=C2N1)([N]3=CC4=CC=CC=C4N3)[Cl-].[Na+]
InChi Code
InChI=1S/2C7H6N2.4ClH.Na.Ru/c2*1-2-4-7-6(3-1)5-8-9-7;;;;;;/h2*1-5H,(H,8,9);4*1H;;/q;;;;;;+1;+3/p-4
InChi Key
WVVOCRYXBTVDRN-UHFFFAOYSA-J
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $211

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    10 mg

    $337

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    25 mg

    $526

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    Cayman Chemical
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    Product Description

    NKP-1339 is a ruthenium complex with anticancer activity.1 It is cytotoxic to HT-29 and SW480 cells (IC50s = 24.46 and 123.3 µM, respectively). NKP-1339 induces mitochondrial apoptosis in SW480 cells. In vivo, NKP-1339 (10.5, 21, and 42 mg/kg) reduces tumor growth in a SaI/N murine fibrosarcoma model.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kapitza, S., Pongratz, M., Jakupec, M.A., et al. Heterocyclic complexes of ruthenium(III) induce apoptosis in colorectal carcinoma cells. J. Cancer Res. Clin. Oncol. 131(2), 101-110 (2005).

    2. Hudej, R., Turel, I., Kanduser, M., et al. The influence of electroporation on cytotoxicity of anticancer ruthenium(III) complex KP1339 in vitro and in vivo. Anticancer Res. 30(6), 2055-2063 (2010).