An internal standard for the quantification of 7-(β-hydroxyethyl)theophylline
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Unlabeled Version(s)
283727-(β-Hydroxyethyl)theophylline
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7-(β-Hydroxyethyl)theophylline-d6

Item No. 35133

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,7-dihydro-7-(2-hydroxyethyl)-1,3-di(methyl-d3)-1H-purine-2,6-dione
Synonyms
  • Etophylline-d6
  • Hydroxyethyltheophylline-d6
Molecular Formula
C9H6D6N4O3
Formula Weight
230.3
Purity
≥99% deuterated forms (d1-d6)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: solubleMethanol: soluble
SMILES
O=C1N(C([2H])([2H])[2H])C(C(N(CCO)C=N2)=C2N1C([2H])([2H])[2H])=O
InChi Code
InChI=1S/C9H12N4O3/c1-11-7-6(8(15)12(2)9(11)16)13(3-4-14)5-10-7/h5,14H,3-4H2,1-2H3/i1D3,2D3
InChi Key
NWPRCRWQMGIBOT-WFGJKAKNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $49

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    5 mg

    $230

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    10 mg

    $435

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    Product Description

    7-(β-Hydroxyethyl)theophylline-d6 is intended for use as an internal standard for the quantification of 7-(β-hydroxyethyl)theophylline (Item No. 28372) by GC- or LC-MS. 7-(β-Hydroxyethyl)theophylline is a methylxanthine phosphodiesterase (PDE) inhibitor.1 It reduces histamine, 5-hydroxytryptamine (5-HT), and bradykinin-induced bronchoconstriction in an anesthetized guinea pig model of bronchial asthma.2 Formulations containing 7-(β-hydroxyethyl)theophylline in combination with theophylline have been used in the treatment of asthma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mizon, J., Skandrani, E., and Mizon, C. Determination of the inhibitory activity of some new substituted theophyllines on the specific phosphodiesterase of cyclic nucleotides. Therapie 26(5), 911-917 (1971).

    2. Ufkes, J.G., Leeuwin, R.S., Ottenhof, M., et al. Efficacy of theophylline and its N-7-substituted derivatives in experimentally induced bronchial asthma in the guinea-pig. Arch. Int. Pharmacodyn. Ther. 253(2), 301-314 (1981).