An alkaloid with diverse biological activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Lotusine

Item No. 35136

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R)-1,2,3,4-tetrahydro-6-hydroxy-1-[(4-hydroxyphenyl)methyl]-7-methoxy-2,2-dimethyl-isoquinolinium
CAS Number
6871-67-6
Synonyms
  • (–)-Lotusine
Molecular Formula
C19H24NO3
Formula Weight
314.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 10 mg/mlEthanol: 3 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
230 nm
SMILES
OC(C=C(CC[N+]1(C)C)C([C@H]1CC2=CC=C(C=C2)O)=C3)=C3OC
InChi Code
InChI=1S/C19H23NO3/c1-20(2)9-8-14-11-18(22)19(23-3)12-16(14)17(20)10-13-4-6-15(21)7-5-13/h4-7,11-12,17H,8-10H2,1-3H3,(H-,21,22)/p+1/t17-/m1/s1
InChi Key
ZKTMLINFIQCERN-QGZVFWFLSA-O
Origin
Plant/Nelumbo nucifera
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $90

    Add

    10 mg

    $168

    Add

    25 mg

    $392

    Add

    50 mg

    $740

    Add
    Product Description

    Lotusine is an alkaloid that has been found in N. nucifera and has diverse biological activities.1,2,3 It increases the level of cAMP in rat myocardium when used at concentrations ranging from 0.1 to 3 µM and the levels of cGMP in rabbit corpus cavernosum in a concentration-dependent manner.2 Lotusine prevents lipid peroxidation induced by doxorubicin (Item No. 15007) in H9c2 embryonic rat cardiomyocytes.1 It also increases left ventricular pressure (LVP), left ventricular end diastolic pressure (LVEDP), and systolic arterial blood pressure (SAP) in anesthetized rats when administered at a dose of 5 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Harishkumar, R., and Selvaraj, C.I. Lotusine, an alkaloid from Nelumbo nucifera (Gaertn.), attenuates doxorubicin-induced toxicity in embryonically derived H9c2 cells. In Vitro Cell. Dev. Biol. Anim. 56(5), 367-377 (2020).

    2. Zhao, Z., Zhang, Y., Yu, X., et al. Effects of lotusine on cyclic nucleotide levels and contractile function in rat myocardium and rabbit corpus cavernosum. Zhongguo Yaolixue Yu Dulixue Zazh 16(3), 202-205 (2002).

    3. Wang, J., Zhao, Z., Zhang, F., et al. Effect of lotusine on hemodynamics in rat and canine. Zhongcaoyao 30(11), 838-340 (1999).