A sesquiterpene lactone with diverse biological activities
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1-O-Acetylbritannilactone

Item No. 35137

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3aS,4S,7aR)-5-[(1S)-4-(acetyloxy)-1-methylbutyl]-3a,4,7,7a-tetrahydro-4-hydroxy-6-methyl-3-methylene-2(3H)-benzofuranone
CAS Number
33627-41-7
Synonyms
  • ABL
  • Inulicin
Molecular Formula
C17H24O5
Formula Weight
308.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
O[C@H]1[C@@]2([H])[C@@](OC(C2=C)=O)([H])CC(C)=C1[C@@H](C)CCCOC(C)=O
InChi Code
InChI=1S/C17H24O5/c1-9(6-5-7-21-12(4)18)14-10(2)8-13-15(16(14)19)11(3)17(20)22-13/h9,13,15-16,19H,3,5-8H2,1-2,4H3/t9-,13+,15+,16+/m0/s1
InChi Key
QKUFZFLZBUSEHN-CZLJMHDISA-N
Origin
Plant/Inula japonica
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $63

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    5 mg

    $213

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    10 mg

    $392

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    25 mg

    $902

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    Product Description

    1-O-Acetylbritannilactone is a sesquiterpene lactone that has been found in I. britannica and has diverse biological activities.1,2 It inhibits LPS-induced production of prostaglandin E2 (PGE2; Item No. 14010) and nuclear translocation of NF-κB in primary rat aorta vascular smooth muscle cells (VSMCs).1 1-O-Acetylbritannilactone (5 and 10 µM) inhibits VEGF-induced capillary tube formation in human umbilical vein endothelial cells (HUVECs).2 It reduces tumor growth in an A549 mouse xenograft model when administered at a dose of 12 mg/kg per day.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, Y.-P., Wen, J.-K., Zheng, B., et al. Acetylbritannilactone suppresses lipopolysaccharide-induced vascular smooth muscle cell inflammatory response. Eur. J. Pharmacol. 577(1-3), 28-34 (2007).

    2. Zhengfu, H., Hu, Z., Huiwen, M., et al. 1-o-acetylbritannilactone (ABL) inhibits angiogenesis and lung cancer cell growth through regulating VEGF-Src-FAK signaling. Biochem. Biophys. Res. Commun. 464(2), 422-427 (2015).