A benzylisoquinoline alkaloid with diverse biological activities
Related Products
Isomer(s)
26612(–)-Stepholidine
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Scoulerine

Item No. 35140

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,8,13,13aS-tetrahydro-3,10-dimethoxy-6H-dibenzo[a,g]quinolizine-2,9-diol
CAS Number
6451-73-6
Synonyms
  • (–)-Scoulerine
  • l-Scoulerine
  • (S)-Scoulerine
Molecular Formula
C19H21NO4
Formula Weight
327.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly SolubleMethanol: Slightly Soluble
SMILES
OC1=C(OC)C=C2CCN(CC3=C(O)C(OC)=CC=C3C4)[C@]4([H])C2=C1
InChi Code
InChI=1S/C19H21NO4/c1-23-17-4-3-11-7-15-13-9-16(21)18(24-2)8-12(13)5-6-20(15)10-14(11)19(17)22/h3-4,8-9,15,21-22H,5-7,10H2,1-2H3/t15-/m0/s1
InChi Key
KNWVMRVOBAFFMH-HNNXBMFYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $54

    Add

    5 mg

    $209

    Add

    10 mg

    $367

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Scoulerine is a benzylisoquinoline alkaloid that has been found in C. cava and has diverse biological activities.1,2,3 It selectively binds to the dopamine D1 and D2 receptors (Kis = 22 and 214 nM, respectively) over the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT2A in HEK293 cells when used at a concentration of 10 µM.1 Scoulerine inhibits proliferation in a panel of leukemia cell lines (IC50s = 2.7-6.5 µM).2 It inhibits methamphetamine-induced conditioned place preference in mice when administered at a dose of 5 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sun, H., Zhu, L., Yang, H., et al. Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D1, D2 and serotonin 5-HT1A multi-action profile. Bioorg. Med. Chem. 21(4), 856-868 (2013).

    2. Habartova, K., Havelek, R., Seifrtova, M., et al. Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cells. Sci. Rep. 8(1), 4829 (2018).

    3. Mi, G., Gao, Y., Yan, H., et al. l-Scoulerine attenuates behavioural changes induced by methamphetamine in zebrafish and mice. Behav. Brain Res. 298(Pt A), 97-104 (2016).