A selective progesterone receptor modulator
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Asoprisnil

Item No. 35170

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[C(E)]-4-[(11β,17β)-17-methoxy-17-(methoxymethyl)-3-oxoestra-4,9-dien-11-yl]-benzaldehyde, 1-oxime
CAS Number
199396-76-4
Synonyms
  • J867
Molecular Formula
C28H35NO4
Formula Weight
449.6
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
C[C@@]12[C@](CC[C@@]2(OC)COC)([H])[C@@]3([H])C([C@](C4=CC=C(C=C4)/C=N/O)([H])C1)=C5C(CC3)=CC(CC5)=O
InChi Code
InChI=1S/C28H35NO4/c1-27-15-24(19-6-4-18(5-7-19)16-29-31)26-22-11-9-21(30)14-20(22)8-10-23(26)25(27)12-13-28(27,33-3)17-32-2/h4-7,14,16,23-25,31H,8-13,15,17H2,1-3H3/b29-16+/t23-,24+,25-,27-,28+/m0/s1
InChi Key
GJMNAFGEUJBOCE-MEQIQULJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $86

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    5 mg

    $363

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    10 mg

    $641

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    25 mg

    $1,066

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    Product Description

    Asoprisnil is a selective progesterone receptor modulator (SPRM).1 It selectively binds to the progesterone receptor over the glucocorticoid receptor. Asoprinil inhibits the proliferation of vaginal epithelium and induces mucification of the vaginal epithelium in guinea pigs. It also inhibits ovulation in guinea pigs when administered at doses greater than 1 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schubert, G., Elger, W., Kaufmann, G., et al. Discovery, chemistry, and reproductive pharmacology of asoprisnil and related 11β-benzaldoxime substituted selective progesterone receptor modulators (SPRMs). Semin. Reprod. Med. 23(1), 58-73 (2005).

    2. DeManno, D., Elger, W., Garg, R., et al. Asoprisnil (J867): A selective progesterone receptor modulator for gynecological therapy. Steroids 68(10-13), 1019-1032 (2003).