A cyclic peptide agonist of MC4R
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PT-141 (acetate)

Item No. 35175

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-L-norleucyl-L-α-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysine (2→7)-lactam, monoacetate
CAS Number
1607799-13-2
Synonyms
  • Bremelanotide Acetate
Molecular Formula
C50H68N14O10 • C2H4O2
Formula Weight
1085.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
CC(O)=O.O=C([C@@H](NC([C@H](NC([C@@H](NC([C@H](CC(NCCCC[C@H](NC1=O)C(O)=O)=O)NC([C@@H](NC(C)=O)CCCC)=O)=O)CC2=CN=CN2)=O)CC3=CC=CC=C3)=O)CCCNC(N)=N)N[C@H]1CC4=CNC5=CC=CC=C45
InChi Code
InChI=1S/C50H68N14O10.C2H4O2/c1-3-4-16-35(58-29(2)65)43(67)64-41-25-42(66)54-20-11-10-18-37(49(73)74)60-46(70)39(23-31-26-56-34-17-9-8-15-33(31)34)62-44(68)36(19-12-21-55-50(51)52)59-45(69)38(22-30-13-6-5-7-14-30)61-47(71)40(63-48(41)72)24-32-27-53-28-57-32;1-2(3)4/h5-9,13-15,17,26-28,35-41,56H,3-4,10-12,16,18-25H2,1-2H3,(H,53,57)(H,54,66)(H,58,65)(H,59,69)(H,60,70)(H,61,71)(H,62,68)(H,63,72)(H,64,67)(H,73,74)(H4,51,52,55);1H3,(H,3,4)/t35-,36-,37-,38+,39-,40-,41-;/m0./s1
InChi Key
MAYUSRUHXFWITM-GBRHMYBBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $63

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    10 mg

    $105

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    25 mg

    $242

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    50 mg

    $454

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    Product Description

    PT-141 is a cyclic peptide agonist of melanocortin receptor 4 (MC4R) and an analog of α-melanocyte stimulating hormone (α-MSH; Item No. 29923).1 It binds to MC3R and MC4R and increases intracellular cAMP levels in HEK293 cells expressing MC4R. It increases dopamine release in the medial preoptic area (mPOA) of the hypothalamus in female rats.2 PT-141 (100 and 200 µg/kg) increases the number of solicitations, an appetitive sexual behavior, by ovariectomized estrogen- and progesterone-primed female rats. Intranasal administration of PT-141 (50 µg/kg) induces penile erections in male rats.1 Formulations containing PT-141 have been used in the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Molinoff, P.B., Shadiack, A.M., Earle, D., et al. PT-141: A melanocortin agonist for the treatment of sexual dysfunction. Ann. N. Y. Acad. Sci. 994(1), 96-102 (2003).

    2. Pfaus, J., Giuliano, F., and Gelez, H. Bremelanotide: An overview of preclinical CNS effects on female sexual function. J. Sex Med. 4(Suppl 4), 269-279 (2007).