A chromogenic substrate for endotoxins
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Boc-LGR-pNA (acetate)

Item No. 35176

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1,1-dimethylethoxy)carbonyl]-L-leucylglycyl-N-(4-nitrophenyl)-L-argininamide, monoacetate
CAS Number
176786-91-7
Synonyms
  • Boc-Leu-Gly-Arg-pNA
  • Boc-Leu-Gly-Arg-p-Nitroanilide
  • Tertbutyloxycarbonyl-Leu-Gly-Arg-p-Nitroanilide
Molecular Formula
C25H40N8O7• C2H4O2
Formula Weight
624.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 15 mg/mlEthanol: 15 mg/ml
λmax
202, 222, 312 nm
SMILES
CC(O)=O.CC(C)(C)OC(N[C@H](CC(C)C)C(NCC(N[C@H](CCCNC(N)=N)C(NC1=CC=C(C=C1)[N+]([O-])=O)=O)=O)=O)=O
InChi Code
InChI=1S/C25H40N8O7.C2H4O2/c1-15(2)13-19(32-24(37)40-25(3,4)5)21(35)29-14-20(34)31-18(7-6-12-28-23(26)27)22(36)30-16-8-10-17(11-9-16)33(38)39;1-2(3)4/h8-11,15,18-19H,6-7,12-14H2,1-5H3,(H,29,35)(H,30,36)(H,31,34)(H,32,37)(H4,26,27,28);1H3,(H,3,4)/t18-,19-;/m1./s1
InChi Key
JUYIJJFZGVXISO-STYNFMPRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    Boc-LGR-pNA is a chromogenic substrate for the detection of bacterial endotoxins.1 Upon enzymatic cleavage by endotoxin-induced amidases, p-nitroanilide (pNA) is released which can be quantified by colorimetric detection at 405 nm as a measure of endotoxin levels.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Harada-Suzuki, T., Morita, T., Iwanaga, S., et al. Further studies on the chromogenic substrate assay method for bacterial endotoxins using horseshoe crab (Tachypleus tridentatus) hemocyte lysate. J. Biochem. 92(3), 793-800 (1982).