An inhibitor of CHIT1 and CHIA
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OATD-01

Item No. 35193

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[4-[(2S,5S)-5-[(4-chlorophenyl)methyl]-2-methyl-4-morpholinyl]-1-piperidinyl]-1H-1,2,4-triazol-3-amine
CAS Number
2088453-21-6
Molecular Formula
C19H27ClN6O
Formula Weight
390.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble
λmax
225 nm
SMILES
C[C@H](OC1)CN(C2CCN(C3=NN=C(N)N3)CC2)[C@H]1CC4=CC=C(C=C4)Cl
InChi Code
InChI=1S/C19H27ClN6O/c1-13-11-26(17(12-27-13)10-14-2-4-15(20)5-3-14)16-6-8-25(9-7-16)19-22-18(21)23-24-19/h2-5,13,16-17H,6-12H2,1H3,(H3,21,22,23,24)/t13-,17-/m0/s1
InChi Key
STWVLEKJQQRGMO-GUYCJALGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $42

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    5 mg

    $183

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    10 mg

    $302

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    25 mg

    $553

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    Product Description

    OATD-01 is an inhibitor of chitotriosidase 1 (CHIT1) and acidic mammalian chitinase (CHIA), also known as AMCase (IC50s = 23 and 9 nM, respectively).1 It is selective for CHIT1 and CHIA over a panel of 98 enzymes at 10 µM. OATD-01 (30 and 100 mg/kg) reduces the degree of lung fibrosis and plasma chitinolytic activity in a mouse model of pulmonary fibrosis induced by bleomycin (Item No. 13877).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Koralweski, R., Dymek, B., Mazur, M., et al. Discovery of OATD-01, a first-in-class chitinase inhibitor as potential new therapeutics for idiopathic pulmonary fibrosis. J. Med. Chem. 63(24), 15527-15540 (2020).