An internal standard for the quantification of phenylalanine
Related Products
Alternative(s)
34845DL-Phenyl-d5-alanine
Unlabeled Version(s)
31498L-Phenylalanine
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L-Phenylalanine-13C6

Item No. 35195

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-phenylalanine-1,2,3,4,5,6-13C6
CAS Number
180268-82-0
Synonyms
  • (–)-Phenylalanine-13C6
Molecular Formula
C3[13C]6H11NO2
Formula Weight
171.2
Purity
≥99% deuterated forms (d1-d6)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
OC([C@@H](N)C[13C]1=[13CH][13CH]=[13CH][13CH]=[13CH]1)=O
InChi Code
InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1/i1+1,2+1,3+1,4+1,5+1,7+1
InChi Key
COLNVLDHVKWLRT-KILZIXFTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $62

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    10 mg

    $117

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    50 mg

    $395

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    100 mg

    $726

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    Product Description

    L-Phenylalanine-13C6 is intended for use as an internal standard for the quantification of phenylalanine by GC- or LC-MS. L-Phenylalanine is an essential amino acid.1,2,3 Blood and brain levels of L-phenylalanine are increased and associated with progressive cognitive impairments, seizures, motor deficits, and autism in patients with phenylketonuria, an inborn error of metabolism characterized by mutations in the gene encoding phenylalanine hydroxylase (PAH). L-Phenylalanine inhibits NMDA-induced currents in primary rat hippocampal neurons (IC50 = 1.71 mM).1 It also assembles into fibrils in vitro that are cytotoxic to PC12 and CHO cells when used at concentrations ranging from 1.16 to 15 mM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Glushakov, A.V., Dennis, D.M., Morey, T.E., et al. Specific inhibition of N-methyl-D-aspartate receptor function in rat hippocampal neurons by L-phenylalanine at concentrations observed during phenylketonuria. Mol. Psychiatry 7(4), 359-367 (2002).

    2. Adler-Abramovich, L., Vaks, L., Carny, O., et al. Phenylalanine assembly into toxic fibrils suggests amyloid etiology in phenylketonuria. Nat. Chem. Biol. 8(8), 701-706 (2012).

    3. Blau, N., van Spronsen, F.J., and Levy, H.L. Phenylketonuria. Lancet 376(9750), 1417-1427 (2010).