A thyroid hormone derivative
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N-Acetyl-L-thyroxine

Item No. 35197

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine
CAS Number
26041-51-0
Synonyms
  • N-acetyl-L-T4
  • N-Acetylthyroxine
  • N-acyl-L-T4
Molecular Formula
C17H13I4NO5
Formula Weight
818.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 14 mg/mLDMSO: 25 mg/mLEthanol: 20 mg/mLPBS (pH 7.2): 0.2 mg/mL
λmax
225 nm
SMILES
IC1=CC(C[C@@H](C(O)=O)NC(C)=O)=CC(I)=C1OC2=CC(I)=C(C(I)=C2)O
InChi Code
InChI=1S/C17H13I4NO5/c1-7(23)22-14(17(25)26)4-8-2-12(20)16(13(21)3-8)27-9-5-10(18)15(24)11(19)6-9/h2-3,5-6,14,24H,4H2,1H3,(H,22,23)(H,25,26)/t14-/m0/s1
InChi Key
NERGVJCCFAPEMR-AWEZNQCLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $160

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    250 mg

    $359

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    500 mg

    $559

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    Product Description

    N-Acetyl-L-thyroxine is an acetylated derivative of L-thyroxine (Item No. 14116).1 It only weakly binds to thyroxine-binding globulin (TBG) in isolated human serum with a relative binding affinity of 25 compared with L-thyroxine. N-Acetyl-L-thyroxine is also a potential impurity in commercial preparations of L-thyroxine.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Snyder, S.M., Cavalieri, R.R., Goldfine, I.D., et al. Binding of thyroid hormones and their analogues to thyroxine-binding globulin in human serum. The Journal of Biological Chemisty 251(21), 6489-6494 (1976).

    2. Panmanad, D., Joshi, M.S., Patil, R., et al. Synthesis and characterization of potential impurities in levothyroxine. Chem. Sci. Trans. 5(4), 1082-1089 (2016).