The levorotary enantiomer of medetomidine
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Product Type

Biochemicals

Research Area

Neuroscience

Levomedetomidine (hydrochloride)

Item No. 35201

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(1R)-1-(2,3-dimethylphenyl)ethyl]-1H-Imidazole, monohydrochloride
CAS Number
190000-46-5
Synonyms
  • (R)-Medetomidine
Molecular Formula
C13H16N2 • HCl
Formula Weight
236.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
C[C@@H](C1=CN=CN1)C2=C(C(C)=CC=C2)C.Cl
InChi Code
InChI=1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H/t11-;/m1./s1
InChi Key
VPNGEIHDPSLNMU-RFVHGSKJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $54

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    5 mg

    $197

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    10 mg

    $341

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    25 mg

    $783

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    Product Description

    Levomedetomidine is the levorotary enantiomer of the racemic α2-adrenergic receptor (α2-AR) agonist medetomidine.1 Unlike medetomidine or the dextrorotary enantiomer dexmedetomidine (Item No. 15581), levomedetomidine does not induce sedation or analgesia when administered alone in dogs.2 However, levomedetomidine does reduce the level of dexmedetomidine-induced sedation in dogs. Formulations containing levomedetomidine have been used as anesthetics.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, S.M., Lee, B., An, H.J., et al. Novel PPARα agonist MHY553 alleviates hepatic steatosis by increasing fatty acid oxidation and decreasing inflammation during aging. Oncotarget 8(28), 46273-46285 (2017).

    2. Kuusela, E., Vainio, O., Kaistinen, A., et al. Sedative, analgesic, and cardiovascular effects of levomedetomidine alone and in combination with dexmedetomidine in dogs. Am. J. Vet. Res. 62(4), 616-621 (2001).